HEPATITIS B, CHRONIC

This study tests a new drug called bepirovirsen in about 857 adults with chronic hepatitis B who are already on standard antiviral therapy. The goal is to see if bepirovirsen can achieve a functional cure, meaning the virus is suppressed and no longer detectable after stopping al…

This study tests a new drug called bepirovirsen to see if it can cure chronic hepatitis B. About 981 adults who are already on standard antiviral therapy will receive either bepirovirsen or a placebo for 24 weeks, then stop all hepatitis B treatments to see if the virus stays sup…

This study tests a new drug called AHB-137 in adults with chronic hepatitis B who are already on standard antiviral pills. The goal is to see if AHB-137 can lower the virus to undetectable levels and possibly allow patients to stop their daily medication. About 86 participants wi…

This study looks at how well and how safely the drug pradefovir mesylate works for people with chronic hepatitis B. About 400 adults aged 18 to 65 with active hepatitis B will take the drug and be followed over time. The main goal is to see if the drug can lower the virus to unde…

This study looks at whether adults with chronic hepatitis B who have been on antiviral drugs for at least 2 years and have no liver scarring can safely stop taking them. The 140 participants will be monitored for virus return and liver problems. The goal is to see if stopping tre…

This study is testing whether a new blood test, called the GAAD score, can improve the detection of liver cancer in people who are at high risk, such as those with cirrhosis or chronic hepatitis. Around 2,100 participants will get an ultrasound and the GAAD blood test every six m…