HARM REDUCTION
Clinical trials for HARM REDUCTION explained in plain language.
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New hope for hardcore smokers: e-cigarettes and cytisine put to the test
Disease control Not yet recruitingThis study looks at whether e-cigarettes or a medication called cytisine can help people who keep smoking despite using nicotine patches, gum, or counseling. Over 4 years, 6,000 adults who smoke at least 5 cigarettes a day will be randomly assigned to try one of these options. Re…
Matched conditions: HARM REDUCTION
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Disease control
Last updated Jun 15, 2026 19:06 UTC
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New tool aims to prevent opioid overdose during dose tapering
Prevention Not yet recruitingThis study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…
Matched conditions: HARM REDUCTION
Sponsor: University of Colorado, Denver • Aim: Prevention
Last updated Jun 15, 2026 19:08 UTC
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Booster session aims to keep drug users in care after hep c cure
Knowledge-focused Not yet recruitingThis study looks at whether a short follow-up session can help people who inject drugs stay engaged with healthcare after finishing hepatitis C treatment. Researchers will also study how discrimination affects treatment and support between injecting partners. About 50 adults and …
Matched conditions: HARM REDUCTION
Phase: NA • Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:07 UTC
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New alert aims to curb opioid risks by flagging therapy phase changes
Knowledge-focused Not yet recruitingThis study tests a computer alert that notifies doctors when an opioid prescription moves a patient into a new stage of treatment (like from short-term to long-term use). The goal is to help doctors reassess pain and risks at these key moments. About 200,000 primary care visits w…
Matched conditions: HARM REDUCTION
Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated Jun 10, 2026 13:28 UTC
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New study tests if talking can tame steroid abuse
Knowledge-focused Not yet recruitingThis study will test a harm reduction program for people who misuse anabolic steroids for looks or performance. Researchers want to see if the program helps them use less steroids over a year and improves their health, mood, and body. The study will include 32 people aged 15 and …
Matched conditions: HARM REDUCTION
Phase: NA • Sponsor: University of Sao Paulo • Aim: Knowledge-focused
Last updated Jun 09, 2026 12:10 UTC
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Can a phone app help people in supportive housing stay stable?
Knowledge-focused Not yet recruitingThis study will test if a technology-based tool is helpful and easy to use for people living in supportive housing who also have substance use issues. About 25 residents and staff will try the tool, which includes videos and rewards, for two weeks. Researchers want to see if it i…
Matched conditions: HARM REDUCTION
Phase: NA • Sponsor: Oregon Research Behavioral Intervention Strategies, Inc. • Aim: Knowledge-focused
Last updated Jun 01, 2026 17:54 UTC
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Doctor alert system aims to boost opioid addiction treatment
Knowledge-focused Not yet recruitingThis study tests whether a computer alert can help doctors identify and treat patients with opioid use disorder. About 200,000 patients will be involved, and doctors will either receive an alert or not. The goal is to see if the alert increases the use of addiction medication lik…
Matched conditions: HARM REDUCTION
Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated May 27, 2026 11:50 UTC