GLIOBLASTOMA MULTIFORME, ADULT

This study tests a new surgical technique for people with a fast-growing brain cancer called glioblastoma. During surgery to remove the tumor, doctors place a piece of the patient's own tissue (from the scalp or skull lining) into the empty space. This flap may help bypass the bl…

This study tests a new approach for people with a fast-growing brain cancer called glioblastoma. Doctors take some of the patient's own blood stem cells, add a protective gene (P140K MGMT), and put them back. This allows the use of stronger chemotherapy to kill more cancer cells …

This phase 3 trial tests whether delivering the drug Avastin directly into the brain's arteries (called SIACI) alongside standard chemotherapy and radiation can help people with newly diagnosed glioblastoma live longer. About 432 adults with this aggressive brain cancer will be r…

This study tests whether giving a higher radiation dose to the most aggressive parts of a glioblastoma tumor, as seen on a special FDOPA PET scan, can help people live longer. It includes 75 adults who are too frail for standard treatment or had only a partial surgery or biopsy. …

This study tests whether adding a focused ultrasound device (NaviFUS) to the standard drug Avastin helps people with recurrent glioblastoma (a type of aggressive brain cancer) live longer without their cancer growing. About 32 adults whose cancer returned after standard treatment…

This study tests a new treatment called TLX101-Tx, which delivers radiation directly to glioblastoma cells, combined with standard chemotherapy (lomustine) in adults whose brain cancer has returned after initial treatment. The goal is to see if the combination works better than c…

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…