EPILEPSY, TEMPORAL LOBE

This study tests brain surgery as a treatment for people whose epilepsy doesn't improve with medication. About 300 children and adults aged 8 and older will have surgery to remove or treat the part of the brain causing seizures. The goal is to stop or greatly reduce seizures, tho…

This pilot study tests a device called NaviFUS that uses low-intensity focused ultrasound to calm overactive brain areas. It involves 16 adults with drug-resistant epilepsy who still have frequent seizures despite trying at least three medications. The goal is to see if the treat…

This early-stage trial tests a one-time injection of special nerve cells (NRTX-1001) into both sides of the brain in 10 adults with drug-resistant epilepsy. The cells are designed to calm overactive brain signals by releasing GABA. The main goal is safety, but researchers will al…

This study screens children and adults aged 8 and older with known or suspected epilepsy, especially those whose seizures are not controlled by medication. Participants undergo tests like EEG, MRI, and PET scans to characterize their epilepsy. The goal is to find suitable candida…

This study explores how the brain recognizes and remembers places, using virtual tours and brain recordings in people with epilepsy. Researchers aim to map the brain regions critical for spatial memory, so surgeons can avoid them during epilepsy surgery. Over 600 participants, in…

This study tests a special MRI method using ferumoxytol, an iron-based contrast agent, to get clearer images of tiny blood vessels in the brain's memory center (hippocampus) in people with temporal lobe epilepsy. Researchers aim to see if these images can help predict who will be…

This study combines advanced MRI scans with intracranial EEG recordings to map brain networks in people with drug-resistant epilepsy. Researchers aim to develop noninvasive imaging biomarkers that predict where seizures start and how they spread. The goal is to improve surgical o…