ENDOMETRIAL NEOPLASMS

This study tests a new drug called LY4175408 for people with advanced lung, endometrial, or triple-negative breast cancer that has spread. The drug is designed to find and attack cancer cells carrying a specific marker (PTK7). The main goals are to check the drug's safety and see…

This early-phase study tests an experimental drug called DM002 in people with advanced solid tumors (cancers of the ovary, prostate, uterus, colon, or other sites). The study has two parts: first, finding a safe dose by giving small groups gradually higher doses; second, giving t…

This early-phase study tests a new oral drug, NKT3964, designed to break down a protein called CDK2 that helps cancer cells grow. The trial includes adults with advanced or metastatic solid tumors, such as ovarian, endometrial, breast, gastric, and lung cancers, whose disease has…

This study tests a new drug, LY4170156, designed to attack cancer cells with a specific marker (folate receptor alpha). It is for people with advanced solid tumors like ovarian, lung, or breast cancer that have not responded to other treatments. The trial has two parts: first fin…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This study tests whether the immunotherapy drug dostarlimab, alone or combined with bevacizumab, works better than standard chemotherapy for women with recurrent clear cell carcinoma of the ovary, uterus, cervix, vagina, or vulva. About 198 participants will be randomly assigned …

This study tests atezolizumab, a drug already approved for some cancers, in people with rare cancers that have high tumor mutational burden (TMB) or microsatellite instability (MSI). About 30 adults and children with these genetic changes will receive the drug to see if their tum…

This study is for people with endometrial cancer that has come back or spread to a few other spots. It tests a new drug called cadonilimab given together with standard chemotherapy and radiation. The goal is to see if this combination can shrink tumors and help people live longer…

This study compares cancer recurrence rates in 1,030 endometrial cancer patients who undergo minimally invasive hysterectomy either with or without a uterine manipulator. The goal is to determine if the device, which helps position the uterus, might accidentally spread cancer cel…

This study is a registry that collects information from about 1,975 people with advanced ovarian or endometrial cancer in Germany. Researchers will track treatments, test results, and how patients feel over time. The goal is to understand real-world care and outcomes, not to test…