COLD EXPOSURE

This early-phase study tests whether spending time in a cool room (around 18°C for 12 hours a day) can make standard immunotherapy drugs work better for people with solid tumors. Twenty-four adults with various solid cancers will receive cold exposure alongside their usual PD-1/P…

This study tests whether taking fish oil for 12 weeks can help the body adapt to cold by activating brown fat, which burns energy to produce heat. Thirty healthy adults aged 18-40 will take either fish oil or a placebo and then undergo a cold chamber challenge. Researchers will m…

This study looks at how repeated short-term cold exposure affects brown adipose tissue (brown fat), a type of body fat that burns energy to generate heat. Twelve healthy adults will undergo a 10-day cold acclimation protocol using cooling blankets. Researchers will take tissue sa…

This study looks at whether eating a high-fat or high-carb energy bar helps soldiers perform better and use energy more efficiently in cold weather (5°C). Eight physically active adults will eat a special bar, then rest, walk with a heavy backpack, and run 2 miles. Researchers wi…

This study looks at whether taking 200mg of caffeine (about two cups of coffee) changes how active your brown fat is when you're mildly cold. Brown fat is a type of body fat that burns energy to generate heat. Researchers will scan 12 healthy adults to measure brown fat activity …