ACUTE LYMPHOCYTIC LEUKEMIA

This study tests whether using two different stem cell donors together can help people with certain blood cancers (like leukemia and myelodysplastic syndromes) live longer without their cancer coming back. About 36 participants will receive a transplant from a half-matched family…

This early-phase study tests a new type of immunotherapy for people with advanced B-cell lymphoma or leukemia that has returned or not responded to standard treatment. Researchers take a patient's own T-cells (a type of immune cell), add a special receptor that targets a protein …

This study tests a new type of CAR-T cell therapy for adults with B-cell acute lymphoblastic leukemia that has come back or not responded to treatment. The therapy uses donor immune cells that are modified to better target and kill cancer cells while reducing side effects like gr…

This study tests the safety and effectiveness of ponatinib in children aged 1 to under 18 with advanced leukemias, lymphomas, or solid tumors that have come back or not responded to other treatments. The goal is to see if the drug can shrink or control the cancer. About 70 childr…

This study tests a new type of immunotherapy for children and young adults (ages 3-39) with B-cell cancers like leukemia or lymphoma that have come back or not responded to standard treatments. The therapy uses the patient's own immune cells, which are modified in a lab to target…

This study tests a new daily pill, LP-118, in up to 100 people with blood cancers that have come back or not responded to treatment. The main goal is to find the safest dose and see how the drug works in the body. Early results will also hint at whether it can shrink tumors or sl…

This study is testing whether a special type of PET scan called 18F FLT can find signs of leukemia or other blood cancers after treatment. About 60 people aged 4 to 80 with relapsed or hard-to-treat leukemia or myeloma will get the scan before and after therapy. The goal is to se…

This study gathers basic survival and complication information from 2000 people receiving stem cell transplants for blood cancers or immune diseases. The goal is to build a database for future research and to improve patient care. No new treatments are being tested; only standard…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured. T…