ABDOMINAL SURGERY

This large Phase 3 trial tested a new antibiotic gel called D-PLEX, which is placed into the surgical wound during abdominal surgery to slowly release the antibiotic doxycycline over time. The goal was to see if it could prevent surgical site infections better than standard care …

This study tested a gel called D-PLEX, applied directly to the surgical wound during abdominal surgery, to see if it could prevent infections. Half of the 202 participants received the gel plus standard care, and the other half received standard care alone. The main goal was to m…

This study tested whether a tool called the ARISCAT score can predict lung complications (like pneumonia or collapsed lung) after major abdominal cancer surgery. Researchers followed 410 adults who had surgery under general anesthesia. The goal was to see if the score could help …

This study took small skin samples from 12 adults during long surgeries (over 4 hours) to measure chemical reactions and genes linked to pain. The goal is to better understand how pain starts at the incision site, which could lead to safer pain relief options. Participants also f…

This study looked at whether giving less fluid during major abdominal surgery helps patients recover better than giving more fluid. Over 3,000 adults having elective abdominal surgery were randomly assigned to either a restrictive (less than 2 liters per day) or liberal (about 6 …

This study looked at how brain activity (measured by EEG) and stress hormones change when patients are intubated and when surgery begins. 52 adults having open abdominal surgery took part. The goal was simply to observe and understand these changes, not to test a treatment.