Young-onset Parkinson disease
MONDO:0017279A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.
Also known as: YOPD, early-onset Parkinson disease, early-onset Parkinson's disease
23 clinical trials for this condition and its sub-types, 9 tagged with Young-onset Parkinson disease itself.
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Sub-types of Young-onset Parkinson disease
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Parkinson disease 10 0 trials
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Parkinson disease 12 0 trials
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Early-onset Parkinson disease 20 0 trials
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Juvenile-onset Parkinson disease 0 trials
3 sub-types
- Kufor-Rakeb syndrome 0 trials Sub-types →
- Parkinson disease 19B, early-onset 0 trials
- Juvenile onset Parkinson disease 19A 0 trials
Most studied deeper sub-types
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New pill aims to slow Parkinson's in genetically targeted patients
Disease control Recruiting nowThis Phase 2 trial tests an oral drug called NEU-411 in 150 adults aged 40-80 with early Parkinson's disease who have a specific genetic marker (LRRK2-driven). The study is double-blind and placebo-controlled, meaning neither patients nor doctors know who gets the real drug. Rese…
Phase 2 • Sponsor: Neuron23 Inc. • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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Stem cell injection aims to replace lost brain cells in Parkinson's
Disease control Recruiting nowThis study tests a single injection of lab-grown nerve cells made from stem cells to treat early-onset Parkinson's disease. The cells are designed to replace the dopamine-producing neurons that are lost in Parkinson's. The trial has two phases: first, a small safety test in 6-12 …
Phase 1/2 • Sponsor: XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Can a dual DNA-RNA approach unlock Parkinson's genetic secrets?
Diagnosis Recruiting nowThis study aims to find the missing genetic causes of Parkinson's disease in people with early-onset or familial forms who haven't received a molecular diagnosis. Researchers will use a combination of whole genome and RNA sequencing to look for hidden genetic variants. The goal i…
Sponsor: University Hospital, Strasbourg, France • Aim: Diagnosis
Last updated Aug 23, 2026 00:00 UTC
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New online therapy aims to ease emotional toll of early Parkinson's
Symptom relief Recruiting nowThis study tests an 8-week online group therapy program for people diagnosed with Parkinson's disease before age 65. The therapy, called Acceptance and Commitment Therapy (ACT), helps participants cope with difficult thoughts and feelings related to their condition. Researchers w…
Sponsor: University of Coimbra • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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Can we decode the hidden subtypes of early Parkinson's?
Knowledge-focused Recruiting nowThis study investigates the biological mechanisms behind young-onset Parkinson's disease, which begins before age 50. Researchers will analyze genetic tests and protein markers in spinal fluid and skin biopsies from 250 participants to identify distinct disease subtypes. The goal…
Sponsor: NYU Langone Health • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Massive Parkinson's registry launches in china to track 100,000 patients
Knowledge-focused Recruiting nowThis study aims to collect health information from 100,000 people with Parkinsonian disorders in China over 10 years. Participants use an online platform to report symptoms, quality of life, and other health details every 3 months. The goal is to better understand how the disease…
Sponsor: Huashan Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC