Toxic encephalopathy
MONDO:0005527A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives.
Also known as: neurotoxicity, neurotoxicity syndrome, neurotoxicity syndromes
75 clinical trials for this condition and its sub-types, 28 tagged with Toxic encephalopathy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Toxic encephalopathy
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Hepatic encephalopathy 45 trials
1 sub-type
- Hepatic coma 0 trials
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Manganese poisoning 1 trial
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Minamata disease 0 trials
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Chronic bilirubin encephalopathy 0 trials
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Exercise and diet may protect the brain during CAR-T cancer treatment
Symptom relief Recruiting nowThis study tests whether a structured exercise program, with or without nutritional advice, can lower the risk and severity of neurotoxicity (brain-related side effects) caused by CAR-T cell therapy in adults with blood cancers. One hundred participants will be randomly assigned …
Sponsor: Instituto de Investigacion Sanitaria INCLIVA • Aim: Symptom relief
Last updated Jul 30, 2026 00:00 UTC
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Your gut bacteria might predict brain radiation injury risk
Knowledge-focused Recruiting nowThis study looks at whether the bacteria in your gut can help predict who might experience side effects from stereotactic radiosurgery (SRS), a precise type of radiation used to treat brain tumors. Researchers will collect stool and blood samples from 150 patients before and afte…
Sponsor: University of Chicago • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC
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Scientists hunt for clues to rare CAR-T side effects in myeloma
Knowledge-focused Recruiting nowThis observational study will follow 30 multiple myeloma patients receiving a standard CAR-T therapy called cilta-cel. Researchers will collect blood, bone marrow, and other samples to find biomarkers linked to rare toxicities like nerve damage, blood issues, and gut problems. Th…
Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Knowledge-focused
Last updated Aug 12, 2026 00:00 UTC
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Eye scanner may predict dangerous brain side effects in cancer treatment
Knowledge-focused Recruiting nowThis study tests whether a non-invasive handheld device that measures pupil size and reactivity can predict neurological side effects in patients receiving CAR-T cell therapy for lymphoma. Researchers will monitor 100 adults before and after treatment to see if pupil changes sign…
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Blood particles may predict chemo nerve pain
Knowledge-focused Recruiting nowThis study is testing whether tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. Researchers will follow 120 adults with various cancers who are receiving specific chemo drugs. Participants give blood samples and answer qu…
Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:26 UTC
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New study aims to catch nerve damage early in chemo patients
Knowledge-focused Recruiting nowThis study looks at how nerves are affected in people who develop nerve damage from the chemotherapy drug cisplatin. Researchers will use a special test to measure nerve activity and compare it to normal nerves. The goal is to better understand this side effect and find early war…
Sponsor: Ka-Wai Ho • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Can we predict dangerous side effects of cancer immunotherapy?
Knowledge-focused Recruiting nowThis study follows 940 adult cancer patients starting immunotherapy to understand why some develop immune-related side effects, especially those affecting the brain and nerves. Researchers will collect blood samples and health data over time to find early warning signs. The goal …
Sponsor: Shantou University Medical College • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Which anesthesia is safer for your brain during tumor surgery?
Knowledge-focused Recruiting nowThis study compares two common anesthesia methods—inhaled gases (sevoflurane or desflurane) versus intravenous propofol—in 84 adults having brain tumor surgery. Researchers will measure brain oxygen levels, swelling, and thinking skills after surgery to see which approach better …
Phase 4 • Sponsor: Georgia Tsaousi • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC