T-B+ severe combined immunodeficiency

MONDO:0044200

T-B+ severe combined immunodeficiency (SCID) is a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T lymphocytes with presence of B lymphocytes, resulting in early-onset severe respiratory viral, bacterial or fungal infections, diarrhea and failure to thrive.

Also known as: T-B+ SCID, T-cell negative B-cell positive SCID

12 clinical trials for this condition and its sub-types, 0 tagged with T-B+ severe combined immunodeficiency itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Severe combined immunodeficiency (37)

Sub-types of T-B+ severe combined immunodeficiency

T-B+ severe combined immunodeficiency due to gamma chain deficiency 10 trials
T-B+ severe combined immunodeficiency due to JAK3 deficiency 2 trials
T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency 1 trial
T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta 0 trials
3 sub-types
- Immunodeficiency 18 0 trials
- Immunodeficiency 19 0 trials
- Immunodeficiency 25 0 trials
T-B+ severe combined immunodeficiency due to CD45 deficiency 0 trials
Combined immunodeficiency, X-linked 0 trials
Immunodeficiency 104 0 trials
Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome 0 trials
Severe combined immunodeficiency due to CORO1A deficiency 0 trials
Severe combined immunodeficiency due to LAT deficiency 0 trials

Including sub-types (12) Tagged with T-B+ severe combined immunodeficiency (0)

Trials to join now! 3 Not yet recruiting 1 Not yet finished but already full! 4 Completed 3 Terminated 1

Bubble boy disease gene therapy trial launches

Disease control Not yet recruiting

This trial tests a gene therapy given by IV for X-linked severe combined immunodeficiency (SCID-X1), a rare immune disorder. Ten participants with no matched donor will receive a lentiviral vector to correct the genetic defect. The goal is to restore immune function and improve s…

Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control

Last updated Aug 29, 2026 00:00 UTC

T-B+ severe combined immunodeficiency

Where it sits in the disease tree

Bubble boy disease gene therapy trial launches