Systemic mycosis

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This phase 2 trial tests an experimental antifungal drug called olorofim in people with a severe, body-wide form of Valley Fever (disseminated coccidioidomycosis) that has not responded to standard treatments. The study also evaluates new questionnaires about symptoms and quality…

This study looks at whether the drug amphotericin B can treat serious fungal infections that break through in people with blood cancers who are already taking antifungal prevention. About 15 adults will receive the drug for 4-6 weeks and be closely monitored. The goal is to see h…

This study is testing whether a blood test called metagenomic next-generation sequencing (mNGS) can accurately diagnose invasive fungal disease in people with blood cancers. These patients are at high risk for such infections, which are often hard to detect and can become severe.…

This study will observe 120 solid organ transplant recipients who have invasive fungal infections. Researchers will track how well the drug liposomal amphotericin B works and its side effects, compared to historical patients who received other antifungal treatments. The goal is t…

This study will look at how the antifungal drug liposomal amphotericin B behaves in 10 critically ill patients with severe fungal infections who are also receiving plasma exchange therapy. The goal is to understand how plasma exchange changes drug levels in the body, which could …