Opportunistic systemic mycosis

This Phase 3 trial tests a new drug called fosmanogepix against standard treatments for life-threatening Candida bloodstream or organ infections. About 450 adults will be randomly assigned to receive either fosmanogepix (first by IV, then as a pill) or the usual IV caspofungin fo…

This study compares a 7-day course of antifungal therapy to the standard 14-day course for children with uncomplicated candidemia (a blood infection caused by Candida fungus). About 420 children who have already received 7 days of treatment will be randomly assigned to stop or co…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study looks at how the immune system responds in critically ill patients with severe abdominal infections. Researchers want to understand why some patients develop a serious fungal infection while others do not. They will measure a specific immune marker (HLA-DR) in 100 adul…