Spinal stenosis

This trial is testing whether ProteiOS®, a growth factor derived from donor bone, can help bones in the lower spine fuse together as effectively as the standard approach using a patient's own bone. Adults with degenerative spine conditions needing lumbar fusion surgery will be ra…

This trial compares two surgical approaches for people who develop spinal stenosis near a previous lumbar fusion. One group receives a smaller surgery (microdecompression alone), while the other gets the standard larger surgery (decompression plus extending the fusion). The study…

This study looks back at medical records of 300 people who had neck spine fusion surgery using a special graft material called NMP®. The goal is to see how safe it is by checking for complications and whether patients needed another surgery within 90 days to 2 years. The research…

This study compares two types of back surgery for people with narrowing of the spine in the neck (cervical stenosis). The goal is to see which surgery better improves nerve function and quality of life. Only 2 adults aged 40 and older who need surgery will take part, and they wil…

This study looks at whether CT scans taken during lumbar spine surgery can detect spinal instability more reliably than standard X-rays taken before surgery. Researchers will review imaging and medical records from 100 adults undergoing surgery for degenerative spine conditions. …

This study tests a new way to inject numbing medicine directly into a specific nerve root to find out which nerve is causing back and leg pain. The goal is to see if this method is safer and more accurate than current techniques. About 80 adults with sciatica who are scheduled fo…

Many people with lumbar spinal stenosis get pain relief from decompression surgery but still do not walk more afterward. This pilot trial tests whether a behavioral program can change that. Researchers randomly assign 75 patients aged 40 to 85 to either the program, which pairs m…

This study compares two surgical options for people who develop spinal stenosis (narrowing of the spine) above a previous fusion site. One group gets decompression alone (removing tissue pressing on nerves), while the other gets decompression plus extended fusion (adding screws a…

This study tests two ways to guide a steroid injection for people with lumbar spinal stenosis, a condition that causes back and leg pain when walking or standing. One method uses X-ray (fluoroscopy) alone, the other adds ultrasound before the X-ray (hybrid). The goal is to see wh…

This study compares two types of keyhole spine surgery for middle-aged and older adults with lumbar spinal stenosis, a condition that causes leg pain and trouble walking. One surgery just removes the tissue pressing on nerves, while the other also fuses the bones together. The go…

This study tests whether a continuous nerve block placed by the surgeon during back surgery can reduce pain and the need for opioids afterward. One hundred adults having lumbar spine surgery will be randomly assigned to receive either the nerve block with a numbing medicine or a …

This study tracks blood sugar changes after an epidural steroid injection for back or leg pain. Researchers will compare 36 adults with and without type 2 diabetes using a continuous glucose monitor worn for 15 days. The goal is to see if the injection causes higher or longer-las…

This study looks at how different types of obesity—central (belly fat) versus peripheral (fat elsewhere)—affect blood loss and complications during major lower back surgery. Researchers will measure pressure inside the abdomen and blood loss in 90 adults having lumbar spine surge…

This study looks at how the severity of cervical spinal stenosis (narrowing of the spine in the neck) affects hand function, including grip strength and fine motor skills. Researchers will measure hand strength and dexterity in 180 adults with neck pain who have had an MRI. The g…

This study looks at 96 adults with lower back pain to see if the damage shown on an MRI matches how much pain they actually feel. Participants will fill out pain and disability questionnaires and get a physical exam. The goal is to help doctors better understand and treat back pa…

This observational study will look at 88 people with chronic neck pain to see if the degree of cervical spine narrowing (stenosis) is linked to pain, central sensitization (an over-sensitive nervous system), movement, and quality of life. Participants will undergo pain tests, sen…

This study will observe how different spinal problems—like scoliosis, stenosis, or herniated discs—change the way people walk and use their back muscles. Researchers will compare 120 older adults (age 60+) with these conditions to healthy volunteers using motion cameras and muscl…