Spermatogenic failure 5
MONDO:0009461A male infertility due to sperm disorder characterized by the presence, in sperm, of a very high percentage of spermatozoa with enlarged head, irregular head shape, multiple flagella, and abnormal midpiece and acrosome. It is generally associated with severe oligoasthenozoospermia and a high rate of sperm chromosomal abnormalities (polyploidy, aneuploidy).
Also known as: SPGF5, macrocephalic sperm head syndrome, macrozoospermia with multiflagellar polyploid spermatozoa, male infertility due to large-headed multiflagellar polyploid spermatozoa, male infertility due to macrozoospermia, male infertility with large-headed, multiflagellar, polyploid spermatozoa, spermatogenic failure 5, spermatogenic failure type 5
68 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
New IVF drug trial halted early: did it help embryo growth?
Disease control TerminatedThis early-stage trial tested whether adding the drug FE999302 to standard IVF hormones could increase the number of high-quality embryos in women undergoing fertility treatment. The study enrolled 310 women aged 18–40 with specific hormone levels. The trial was terminated early,…
Phase: PHASE1 • Sponsor: Ferring Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
-
Timing of fertility drug may affect egg quality in IVF
Disease control TerminatedThis early-phase study looked at whether giving an extra fertility drug (FE 999302) at different times during ovarian stimulation could improve the number of good-quality embryos in women undergoing IVF. The trial included 106 women with high ovarian reserve and was stopped early…
Phase: PHASE1 • Sponsor: Ferring Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
-
Does Dad's smoking harm fertility? new study investigates
Knowledge-focused TerminatedThis study looked at how a man's smoking habits might affect a couple's ability to have a baby. Researchers compared fertile and infertile couples, measuring smoking markers like carbon monoxide and cotinine in blood, semen, and hair. The goal was to understand if smoking damages…
Phase: NA • Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC