Spermatogenic failure 14

This study tests a new way to prepare sperm for in vitro fertilization (IVF) called HyperSperm. It compares the safety and effectiveness of this method to standard sperm preparation. The trial will involve 202 couples undergoing IVF and will measure how many embryos are healthy (…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase pregnancy rates. About 288 women with infertility will be randomly assigned to receive either standard IUI or IUI with PRP-treated…

This study tests whether a modified dual trigger (a mix of HCG and two doses of a GnRH agonist) works better than the standard HCG trigger for ovulation in women undergoing IVF. About 196 women with normal egg reserves will participate. The goal is to see if the new method improv…

This study tests whether giving two medications (a GnRH agonist and HCG) instead of just HCG can help women with low ovarian response produce more mature eggs for IVF. About 164 women will be randomly assigned to receive either the double trigger or the standard HCG trigger. The …

This study compares a new method that combines a non-invasive genetic test (NICS) with artificial intelligence (AI) against the standard way of picking embryos by looks alone. It includes 520 women aged 35-43 or with a history of recurrent miscarriage who are doing IVF. The goal …

This study tests an AI-driven device called BAIBYS™ that automatically selects sperm based on movement, size, and shape for use in IVF. Half of the eggs from each couple will be fertilized using sperm chosen by the AI, and the other half using the standard manual method. The goal…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase the chance of pregnancy. About 288 women with infertility will be randomly assigned to receive either PRP-treated sperm or standar…

This study will compare two advanced sperm selection techniques—PICSI and the ZyMot device—used during ICSI (a type of IVF). The goal is to see which method leads to more pregnancies. 300 couples will take part, with women aged 20-39. The results could help fertility clinics choo…

This study looks at a fertility drug called corifollitropin alfa in women aged 36 to 40 who are doing IVF. The goal is to see if the drug is safe and helps produce eggs. Researchers will track side effects and pregnancy rates over one year.

This study tests whether taking progesterone (a hormone) after intrauterine insemination (IUI) increases the chance of pregnancy in women who also took letrozole to stimulate their ovaries. About 690 women in Denmark will be randomly assigned to receive either progesterone vagina…

This study tests whether adding pure platelet-rich plasma (P-PRP) to sperm samples can improve sperm movement (motility) in a lab. Researchers will first standardize how to make P-PRP, then compare sperm quality after 24 hours with and without P-PRP. The trial involves 248 partic…

This study will look back at records from 92 IVF patients whose embryos came from abnormally fertilized eggs. Researchers want to see how often these embryos lead to pregnancy and live birth. The goal is to help fertility doctors make better decisions about whether to use such em…

This study tests two different calcium treatments (ionophores) to help eggs fertilize during IVF when previous attempts failed. Researchers will compare which treatment works better and check embryo health. The study involves 20 couples with a history of low fertilization.

This study will measure microplastics in semen, follicular fluid, and other samples from 1000 men and women seeking fertility treatment. Researchers will check if higher microplastic levels are linked to lower pregnancy rates and poorer egg or sperm quality. The goal is to better…

This observational study looks at embryos from IVF that are not used for pregnancy to find molecular patterns related to embryo quality. Researchers hope to learn why some embryos are healthy and others are not, which could improve future fertility treatments. About 150 patients …

This study tests whether rinsing (flushing) ovarian follicles during egg retrieval can increase the number of mature eggs collected for IVF. In 75 women undergoing IVF, one ovary will be flushed and the other will not, and the egg yields will be compared. The goal is to see if th…