Skin squamous cell carcinoma

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

This trial investigates whether the immunotherapy drug cemiplimab can shrink advanced cutaneous squamous cell carcinoma in people who have received a kidney transplant. Because immunotherapy can trigger organ rejection, participants also receive the steroid prednisone to protect …

This study tests a new type of radiation called FLASH therapy, which delivers the entire dose in milliseconds instead of minutes. The goal is to see if it can treat skin cancers (squamous cell and basal cell carcinomas) just as well as standard radiation but with fewer side effec…

This phase 2 trial tests two drugs, cemiplimab and cetuximab, given before surgery to people with advanced skin cancer that is hard to remove. The goal is to shrink the tumor enough to make surgery easier or even unnecessary. The study will enroll 27 participants across three sit…

This study tests two drugs together—pucotenlimab and becotatug vedotin—for people with advanced cutaneous squamous cell carcinoma that cannot be removed by surgery. The goal is to see if the combination shrinks tumors better than current treatments. About 38 participants will rec…

This study looks at whether a routine blood test measuring D-dimer levels can predict if the immunotherapy drug cemiplimab will control advanced cutaneous squamous cell carcinoma. Researchers will follow 116 patients starting cemiplimab in regular care, comparing disease control …

This study tests whether injecting two dyes around the tumor and into cancerous lymph nodes can help surgeons spot hidden cancer spread in head and neck cancer. Twenty adults with oral cavity or head and neck skin cancer will receive the dyes before surgery. The goal is to see if…

This study looks back at 238 patients with a common skin cancer called squamous cell carcinoma. Researchers will compare special skin photos (dermoscopic images) with lab results from removed tumors. The goal is to see if certain features in the photos can tell how deep the cance…

This study looks at whether using a high-frequency ultrasound before surgery for common skin cancers on the head and neck can help surgeons remove the entire tumor the first time. About 400 adults with basal or squamous cell skin cancer will be in the study. Some will get the sta…