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Schizoaffective disorder
MONDO:0005487A disorder in which the individual suffers from both symptoms that qualify as schizophrenia and symptoms that qualify as a mood disorder (e.g., depression or bipolar disorder) for a substantial portion (but not all) of the active period of the illness; for the remainder of the active period of the illness, the individual suffers from delusions or hallucinations in the absence of prominent mood symptoms.
279 clinical trials for this condition and its sub-types, 228 tagged with Schizoaffective disorder itself.
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Sub-types of Schizoaffective disorder
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Schizoaffective bipolar disorder 5 trials
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Heart risk check for schizophrenia drugs
Disease control Stopped earlyThis study aimed to see how two antipsychotic drugs, aripiprazole and ziprasidone, affect heart risk in people with schizophrenia, schizoaffective disorder, or bipolar disorder. Researchers measured blood fats and heart electrical changes in 48 adults over 12 months. The trial wa…
Phase 3 • Sponsor: Northwestern University • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Brain zapping trial for Schizophrenia's 'Negative Symptoms' ends early
Symptom relief Stopped earlyThis study tested whether a non-invasive brain stimulation technique called TMS could help reduce negative symptoms of schizophrenia, like low motivation and reduced facial expression. The trial enrolled 47 adults with schizophrenia or schizoaffective disorder and compared active…
Sponsor: Beth Israel Deaconess Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 14:03 UTC
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Brain zaps and computer games: a new hope for schizophrenia fog?
Symptom relief Stopped earlyThis pilot study tested whether combining repetitive transcranial magnetic stimulation (rTMS) with computerized cognitive training could help adults with schizophrenia who have thinking and memory problems. Twelve participants received either active or sham rTMS followed by cogni…
Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Brain chemical oxytocin tested to ease social struggles in schizophrenia
Symptom relief Stopped earlyThis study looked at whether oxytocin, a natural brain chemical that helps with social bonding, could improve social functioning in veterans with schizophrenia. Researchers planned to give oxytocin and use brain scans to see who might benefit. The study was stopped early, so resu…
Phase 2 • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Eye test may predict schizophrenia drug success
Symptom relief Stopped earlyThis study aimed to see if a simple eye scan could predict which people with early schizophrenia would benefit from a drug called sodium nitroprusside. The drug was given to reduce psychosis symptoms like delusions and hallucinations. Only one person enrolled before the study was…
Phase 2 • Sponsor: Beth Israel Deaconess Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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New tool could help patients stay safe on lithium
Knowledge-focused Stopped earlyThis study tested a French version of a questionnaire that measures how much patients know about lithium, a drug used for bipolar and schizoaffective disorders. Researchers wanted to see if higher knowledge scores matched safe lithium levels in the blood. The study included 22 ho…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Brain zapping study targets smoking in schizophrenia
Knowledge-focused Stopped earlyThis study tested whether a non-invasive brain stimulation technique called deep rTMS could change brain activity and reduce smoking in people with schizophrenia. Researchers used brain scans to measure changes in brain connections and smoking behavior. The study was small and en…
Sponsor: Stony Brook University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Could a gentle brain zap quiet voices in schizophrenia?
Knowledge-focused Stopped earlyThis small, early study tested a new approach called Auditory Control Enhancement (ACE) for people with schizophrenia who hear voices (auditory hallucinations) that don't respond to medication. ACE combines a mild brain stimulation technique called tDCS with cognitive training. T…
Sponsor: Brian A Coffman, PhD • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Online tool for psychosis support tested in clinics – but study stopped early
Knowledge-focused Stopped earlyThis study looked at whether a digital platform called Horyzons could be used in clinics that help young people with early psychosis. The platform offers therapy content and a safe social network. Researchers wanted to understand what helps or hinders its use in real-world care. …
Sponsor: University of North Carolina, Chapel Hill • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:15 UTC