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Riley-Day syndrome
MONDO:0009131A congenital disorder caused by mutations in the IKBKAP gene. It is characterized by damage of the sympathetic and parasympathetic and sensory nervous system.
Also known as: Dysautonomia, Familial, HSAN 3, HSAN III, HSAN3, HSN 3, Riley Day syndrome, Riley-Day syndrome, familial dysautonomia
3 clinical trials for this condition and its sub-types.
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New dissolving film may stop dangerous episodes in rare nerve disease
Symptom relief ENROLLING_BY_INVITATIONThis study tests a medicated film placed under the tongue to quickly ease severe episodes (autonomic crises) in people with familial dysautonomia. The film contains dexmedetomidine, a drug that calms the body's stress response. Researchers will check if it reduces symptoms like h…
Phase: PHASE2 • Sponsor: NYU Langone Health • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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New under-the-tongue film may stop dangerous attacks in rare nerve disease
Symptom relief OngoingThis small pilot study is testing whether a medicated film placed under the tongue can safely and effectively stop autonomic crises in people with familial dysautonomia at home. Five adults who have had previous crises and tolerated a similar IV drug are enrolled. The goal is to …
Phase: PHASE2 • Sponsor: NYU Langone Health • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC