Retinal degeneration
MONDO:0004580Degeneration of the retina.
Also known as: retina degeneration, retina, Degeneration Of
586 clinical trials for this condition and its sub-types, 41 tagged with Retinal degeneration itself.
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Sub-types of Retinal degeneration
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Inherited retinal dystrophy 41 trials · 513 incl. sub-types
105 sub-types
- Age-related macular degeneration 190 trials · 334 incl. sub-types Sub-types →
- Retinitis pigmentosa 84 trials · 89 incl. sub-types Sub-types →
- Hereditary macular dystrophy 3 trials · 72 incl. sub-types Sub-types →
- Cone-rod dystrophy 17 trials · 21 incl. sub-types Sub-types →
- ABCA4-related retinopathy 7 trials · 13 incl. sub-types Sub-types →
- Leber congenital amaurosis 11 trials · 13 incl. sub-types Sub-types →
- RPE65-related recessive retinopathy 5 trials · 8 incl. sub-types Sub-types →
- BEST1-related dominant retinopathy 1 trial · 7 incl. sub-types Sub-types →
- RHO-related retinopathy 0 trials · 7 incl. sub-types Sub-types →
- RPGR-related retinopathy 0 trials · 7 incl. sub-types Sub-types →
- Choroideremia 6 trials Sub-types →
- PRPF31-related retinopathy 1 trial · 4 incl. sub-types Sub-types →
- X-linked retinoschisis 4 trials
- Ornithine aminotransferase deficiency 4 trials
- ELOVL4-related maculopathy 0 trials · 3 incl. sub-types Sub-types →
- RLBP1-related retinopathy 2 trials · 3 incl. sub-types Sub-types →
- Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations 3 trials
- BEST1-related recessive retinopathy 0 trials · 2 incl. sub-types Sub-types →
- EYS-related retinopathy 1 trial · 2 incl. sub-types Sub-types →
- LCA5-related retinopathy 1 trial · 2 incl. sub-types Sub-types →
- PRPH2-related retinopathy 1 trial · 2 incl. sub-types Sub-types →
- Revesz syndrome 2 trials
- Late-onset retinal degeneration 2 trials
- AIPL1-related retinopathy 1 trial Sub-types →
- ATF6-related retinopathy 0 trials · 1 incl. sub-types Sub-types →
- CNGB1-related retinopathy 0 trials · 1 incl. sub-types Sub-types →
- FLVCR1-related retinopathy with or without ataxia 0 trials · 1 incl. sub-types Sub-types →
- GUCY2D retinopathy 0 trials · 1 incl. sub-types Sub-types →
- RDH5-related retinopathy 0 trials · 1 incl. sub-types Sub-types →
- Retinoschisis of fovea 1 trial
- ADAM9-related retinopathy 0 trials Sub-types →
- CACNA1F-related retinopathy 0 trials Sub-types →
- CACNA2D4-related retinopathy 0 trials Sub-types →
- CDHR1-related retinopathy 0 trials Sub-types →
- CERKL-related retinopathy 0 trials Sub-types →
- CNGA1-related retinopathy 0 trials Sub-types →
- CNGA3-related retinopathy 0 trials Sub-types →
- CRX-related retinopathy 0 trials Sub-types →
- GNAT2-related retinopathy 0 trials Sub-types →
- GPR179-related retinopathy 0 trials Sub-types →
- GRM6-related retinopathy 0 trials Sub-types →
- GUCA1A-related retinopathy 0 trials Sub-types →
- HGSNAT-related retinopathy 0 trials Sub-types →
- IDH3B-related retinopathy 0 trials Sub-types →
- IMPDH1-related retinopathy 0 trials Sub-types →
- IMPG1-related dominant retinopathy 0 trials Sub-types →
- IMPG1-related recessive retinopathy 0 trials Sub-types →
- IMPG2-related dominant retinopathy 0 trials Sub-types →
- IMPG2-related recessive retinopathy 0 trials Sub-types →
- KCNV2-related retinopathy 0 trials Sub-types →
- KIZ-related retinopathy 0 trials Sub-types →
- LRIT3-related retinopathy 0 trials Sub-types →
- MAK-related retinopathy 0 trials Sub-types →
- MERTK-related retinopathy 0 trials Sub-types →
- MRCS syndrome 0 trials
- NMNAT1-related retinopathy 0 trials Sub-types →
- NYX-related retinopathy 0 trials Sub-types →
- Oguchi disease 0 trials Sub-types →
- PCARE-related retinopathy 0 trials Sub-types →
- PDE6A-related retinopathy 0 trials Sub-types →
- PDE6C-related retinopathy 0 trials Sub-types →
- PDE6G-related retinopathy 0 trials Sub-types →
- PROM1-related retinopathy 0 trials Sub-types →
- PRPF8-related retinopathy 0 trials Sub-types →
- RAB28-related retinopathy 0 trials Sub-types →
- RD3-related retinopathy 0 trials Sub-types →
- RDH12-related dominant retinopathy 0 trials
- RDH12-related recessive retinopathy 0 trials Sub-types →
- REEP6-related retinopathy 0 trials Sub-types →
- RP1-related dominant retinopathy 0 trials
- RP1-related recessive retinopathy 0 trials
- RP2-related retinopathy 0 trials Sub-types →
- RPE65-related dominant retinopathy 0 trials Sub-types →
- SNRNP200-related dominant retinopathy 0 trials Sub-types →
- SPATA7-related retinopathy 0 trials Sub-types →
- Sorsby fundus dystrophy 0 trials Sub-types →
- TOPORS-related retinopathy 0 trials Sub-types →
- TRPM1-related retinopathy 0 trials Sub-types →
- TTLL5-related retinopathy 0 trials Sub-types →
- X-linked intellectual disability-limb spasticity-retinal dystrophy-diabetes insipidus syndrome 0 trials
- X-linked retinal dysplasia 0 trials
- Aceruloplasminemia 0 trials
- Amaurosis-hypertrichosis syndrome 0 trials
- Choroideremia-deafness-obesity syndrome 0 trials
- Dystrophies primarily involving the retinal pigment epithelium 0 trials
- Ectopia lentis-chorioretinal dystrophy-myopia syndrome 0 trials
- Familial benign flecked retina 0 trials
- Foveal hypoplasia-presenile cataract syndrome 0 trials
- Helicoid peripapillary chorioretinal degeneration 0 trials
- Infantile cerebellar-retinal degeneration 0 trials
- Macular degeneration, early-onset 0 trials
- Microcephaly and chorioretinopathy 1 0 trials
- Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability 0 trials
- Microcornea-myopic chorioretinal atrophy 0 trials
- Oligocone trichromacy 0 trials
- Pigmented paravenous retinochoroidal atrophy 0 trials
- Progressive bifocal chorioretinal atrophy 0 trials
- Progressive retinal dystrophy due to retinol transport defect 0 trials
- Retinal degeneration-nanophthalmos-glaucoma syndrome 0 trials
- Retinal dystrophies primarily involving Bruch's membrane 0 trials Sub-types →
- Retinal dystrophy in systemic or cerebroretinal lipidoses 0 trials
- Retinal dystrophy with inner retinal dysfunction and ganglion cell anomalies 0 trials
- Retinal dystrophy, X-linked, Gardner-Hardcastle type 0 trials
- Retinoschisis, autosomal dominant 0 trials
- Vitreoretinal dystrophy 0 trials
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Macular degeneration 212 trials · 429 incl. sub-types
9 sub-types
- Degeneration of macula and posterior pole 0 trials · 354 incl. sub-types Sub-types →
- Stargardt disease 35 trials · 36 incl. sub-types Sub-types →
- Macular retinal edema 20 trials · 28 incl. sub-types Sub-types →
- Vitelliform macular dystrophy 6 trials · 10 incl. sub-types Sub-types →
- Autosomal recessive bestrophinopathy 2 trials
- Isolated macular dystrophy 0 trials
- Macular degeneration, early-onset 0 trials
- Occult macular dystrophy 0 trials
- Patterned macular dystrophy 0 trials Sub-types →
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Retinoschisis 5 trials · 6 incl. sub-types
5 sub-types
- X-linked retinoschisis 4 trials
- Retinoschisis of fovea 1 trial
- Bullous retinoschisis 0 trials
- Flat retinoschisis 0 trials
- Retinoschisis, autosomal dominant 0 trials
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Peripheral retinal degeneration 1 trial · 2 incl. sub-types
6 sub-types
- Retinal lattice degeneration 1 trial
- Blessig's cysts 0 trials
- Cobblestone retinal degeneration 0 trials
- Pseudoretinitis pigmentosa 0 trials
- Secondary vitreoretinal degeneration 0 trials
- Senile reticular retinal degeneration 0 trials
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Cone dystrophy 1, X-linked 0 trials
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Cone dystrophy 5, X-linked 0 trials
Most studied deeper sub-types
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Can a single gene injection preserve sight in inherited blindness?
Cure Recruiting nowThis trial tests a gene therapy called SPVN20, given as a single injection into the eye, for people with advanced rod-cone dystrophy, a genetic condition that causes progressive vision loss. The study includes adults with a confirmed genetic diagnosis and some remaining cone cell…
Phase 1/2 • Sponsor: SparingVision • Aim: Cure
Last updated Sep 10, 2026 00:00 UTC
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Gene therapy injection aims to save sight in rare eye disease
Disease control Recruiting nowThis early-phase trial tests a new gene therapy called VG801 for Stargardt disease, a genetic condition that causes vision loss. Fifteen people aged 6 and older will receive a single injection under the retina. The main goal is to check safety, but researchers will also measure a…
Phase 1/2 • Sponsor: VeonGen Therapeutics GmbH • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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Could a diabetes pill protect eyesight in advanced dry AMD?
Disease control Recruiting nowThis study tests whether dapagliflozin, a drug used for diabetes, can slow the progression of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 70 adults aged 50 and older with this condition will take the drug for 12 month…
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Stem cell eye treatment could restore sight in retinal disease patients
Disease control Recruiting nowThis study tests a new treatment called OpCT-001 for people with inherited eye diseases that damage the retina, such as retinitis pigmentosa. The treatment involves injecting special photoreceptor cells, made from stem cells, into the back of the eye to replace lost cells. The tr…
Phase 1/2 • Sponsor: BlueRock Therapeutics • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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Gene therapy injection aims to save sight in rare genetic disease
Disease control Recruiting nowThis early-stage trial tests a single injection of AXV-101 gene therapy into one eye of 12 children and teens (ages 4-17) with Bardet-Biedl syndrome type 1, a rare genetic condition that causes progressive vision loss. The main goal is to check safety and find the right dose, whi…
Early phase 1 • Sponsor: Axovia Therapeutics • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
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Could stem cells restore sight in damaged eyes?
Disease control Recruiting nowThis study tests whether injecting a person's own bone marrow stem cells into or near the eye can help treat various retinal and optic nerve diseases, including age-related macular degeneration, retinitis pigmentosa, and glaucoma. Participants receive stem cell injections via dif…
Sponsor: MD Stem Cells • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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Scientists test brain chip to restore sight in the blind
Disease control Recruiting nowThis early-stage trial is testing a brain implant designed to create artificial vision in people who are blind. Five participants will have a wireless device surgically placed in the part of the brain that processes vision. The study will check if the device is safe and whether i…
Sponsor: Illinois Institute of Technology • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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Experimental gene injection aims to halt rare childhood blindness
Disease control Recruiting nowThis study tests a gene therapy called OPGx-001 for people with vision loss caused by LCA5 gene mutations. The treatment is a one-time injection under the retina. The goal is to see if it is safe and can slow or stop vision loss. The study involves 22 participants aged 4 and olde…
Phase 1/2 • Sponsor: Opus Genetics, Inc • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Scientists harvest cells to grow mini retinas in lab
Knowledge-focused Recruiting nowThis study collects skin, hair, blood, urine, or saliva samples from people with certain eye diseases (like macular degeneration) and from healthy volunteers. Researchers will turn these samples into stem cells in the lab to study how the diseases develop and to test potential ne…
Sponsor: National Eye Institute (NEI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Night vision test could reveal severity of eye disease
Knowledge-focused Recruiting nowThis study looks at how well people with retinal diseases like retinitis pigmentosa and Stargardt's disease see in the dark. Researchers want to find out if measuring dark adaptation can help detect and track these conditions. Healthy volunteers and people with retinal disease ag…
Sponsor: National Eye Institute (NEI) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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New eye scans could revolutionize how we see retinal disease
Knowledge-focused Recruiting nowThis study uses special cameras to take ultra-detailed pictures of the back of the eye in people with retinal diseases like macular degeneration and retinitis pigmentosa. Researchers aim to develop new ways to diagnose and track these conditions by measuring cell density and func…
Sponsor: Food and Drug Administration (FDA) • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Scientists zoom in on eye cells to unlock secrets of blindness
Knowledge-focused Recruiting nowThis study uses a special camera called an adaptive optics scanning laser ophthalmoscope to take incredibly detailed pictures of the retina, the light-sensitive layer at the back of the eye. Researchers will compare images from healthy people and those with eye diseases like Star…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Eye zap study seeks to prove what patients already feel
Knowledge-focused Recruiting nowThis study looks at people with retinitis pigmentosa and similar eye diseases who already use a device called OkuStim® that sends mild electrical pulses to the eye. Many patients report temporary improvements in vision right after treatment, but these haven't been measured in a s…
Sponsor: Okuvision GmbH • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Super-Scope for eyes: imaging trial spots hidden clues in blindness
Knowledge-focused Recruiting nowThis study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…
Sponsor: Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC