Renal carcinoma

This study tested a new device that uses focused ultrasound (histotripsy) to break apart solid kidney tumors without making any cuts. Twenty adults with small, non-spreading kidney tumors were treated. The main goals were to see if the device could fully cover the tumor and if th…

This study tested a personalized vaccine made from a patient's own tumor cells fused with immune cells (dendritic cells) to treat stage IV kidney cancer. The vaccine was given with a drug called GM-CSF to boost immune response. The main goal was to check safety and side effects i…

This early-stage trial tests an experimental antibody called JS004, which targets a protein on immune cells called BTLA, to see if it can help the immune system fight advanced solid tumors like melanoma, kidney cancer, and bladder cancer. The study includes JS004 alone or combine…

This phase 2 trial tests an experimental drug called LDP, an anti-PD-L1 monoclonal antibody that helps the immune system attack cancer cells. It enrolls adults with muscle-invasive bladder cancer, non-clear cell kidney cancer, or advanced penile cancer. Participants receive LDP i…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This early-phase study tested stereotactic radiotherapy, a precise type of radiation, on 13 people with small kidney cancers (≤4 cm). The goal was to find the highest safe dose by gradually increasing the radiation in four steps. Participants were followed for up to 5 years to mo…

This completed study tested whether a special type of MRI (multiparametric MRI) can accurately tell the difference between benign and malignant small kidney tumors. About 387 adults with small solid kidney masses (1.5-4 cm) were scanned before surgery or biopsy. The goal was to s…

This trial tests whether a software tool called the hypotension prediction index (HPI) can help prevent acute kidney injury after robotic-assisted urologic surgery. The tool uses arterial pressure data to forecast drops in blood pressure during the operation, allowing doctors to …

This study tested two types of nerve blocks—Quadratus Lumborum (QL) and Erector Spinae (ESP)—to see which provides better pain relief after abdominal surgery. 100 adults having surgery for colorectal, prostate, or kidney cancer, or gallbladder removal, received one of the blocks …

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This completed study examined whether a specific variation in the VEGF gene (rs699947) is linked to a higher risk of developing kidney cancer in people who have received a kidney transplant. Researchers analyzed DNA from 272 transplant patients, some of whom had kidney cancer. Th…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This completed study looked at how kidney cancers are found—either because a patient had symptoms or by chance during a scan for something else. Researchers reviewed 1000 patients who had surgery for kidney lesions in the Czech Republic. The goal was to see which detection method…

This study tested whether a 3D navigation system can help surgeons remove kidney tumors more precisely during robot-assisted surgery. The system uses CT and MRI scans to create a 3D model, and a small sensor attached to the kidney tracks movement. The goal was to see if the navig…

This study asked 167 people with cancer (and their caregivers) what they value most during pharmacy consultations for oral cancer drugs. Using a survey method, researchers identified key preferences to help hospitals design better support services. The goal was to improve patient…

This study looked at people with advanced solid tumors (like lung, bladder, or melanoma) who had been on immunotherapy for one year and whose disease was stable. Half stopped treatment and half continued. The goal was to see if stopping early affected how long until the cancer pr…