Raynaud disease
MONDO:0008364An episodic vasoconstriction resulting in discoloration of the skin and pain in the affected areas, often involving fingers or toes. Classically associated with triphasic color changes (white, blue, red) but may be biphasic. Often occurs in response to cold temperatures or emotional stress. May be primary or secondary to an underlying autoimmune disease.
Also known as: Raynaud disease, Raynaud syndrome, Raynaud's disease, Raynaud's syndrome, Raynaud's syndrome (disorder) [ambiguous], secondary Raynaud disease, secondary Raynaud phenomenon, secondary Raynaud's disease
14 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Could a painless microneedle pad ease Raynaud's in scleroderma?
Disease control Not yet recruitingThis Phase 3 trial is testing whether a microneedle pad delivering botulinum toxin A can improve symptoms of Raynaud's phenomenon and digital ulcers in people with systemic sclerosis. The study compares the microneedle treatment to a placebo, measuring changes in finger temperatu…
Phase: PHASE3 • Sponsor: Khon Kaen University • Aim: Disease control
Last updated Aug 18, 2026 04:00 UTC
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Oxygen chamber therapy put to the test for dozens of diseases
Disease control Not yet recruitingThis study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …
Phase: PHASE4 • Sponsor: Jay C. Buckey Jr. • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Can an inhaled powder calm the painful Cold-Finger attacks of scleroderma?
Symptom relief Not yet recruitingThis study tests an inhaled powder called LIQ861 (treprostinil) in adults with scleroderma who have frequent, painful Raynaud's attacks—episodes where fingers or toes turn color and become numb or tingly. About 75 participants will be randomly assigned to receive either a dose th…
Phase: PHASE2 • Sponsor: Liquidia Technologies, Inc. • Aim: Symptom relief
Last updated Aug 09, 2026 00:00 UTC
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Botox shots aim to save limbs in rare Smoker's disease
Symptom relief Not yet recruitingThis study tests whether injecting botulinum toxin (Botox) into the hands or feet can help people with Buerger's disease, a rare condition that blocks blood flow and causes severe pain. Eight adults with critical limb ischemia will receive a single injection session and be follow…
Phase: PHASE3 • Sponsor: University Hospital, Toulouse • Aim: Symptom relief
Last updated Jul 25, 2026 00:00 UTC