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Prolymphocytic leukemia
MONDO:0001023A mature B- or T- cell leukemia with progressive clinical course. It is characterized by the presence of medium-sized lymphocytes with visible nucleoli (prolymphocytes) in the peripheral blood, bone marrow, and spleen.
Also known as: prolymphocytic leukaemia (B or T), prolymphocytic leukaemia (B or T-cell), prolymphocytic leukemia, prolymphocytic leukemia (B or T), prolymphocytic leukemia (B or T-cell)
1978 clinical trials for this condition and its sub-types, 20 tagged with Prolymphocytic leukemia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Prolymphocytic leukemia
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T-cell prolymphocytic leukemia 17 trials
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B-cell prolymphocytic leukemia 7 trials
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Stem cell transplant study seeks best way to prevent immune attack
Disease control CompletedThis study tested different drug combinations to prevent graft-versus-host disease (GVHD) in 174 people with blood cancers receiving stem cells from an unrelated donor. GVHD is a serious side effect where donor cells attack the patient's body. The goal was to find which drug regi…
Phase 3 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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Can a targeted drug tame CLL? small trial seeks answers
Disease control CompletedThis Phase 2 trial tested the drug dasatinib in 17 people with chronic lymphocytic leukemia (CLL) who had already received other treatments. The goal was to see if dasatinib could shrink or control the cancer. Participants took the drug by mouth twice daily, and doctors checked f…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Promising combo tackles tough blood cancers in early trial
Disease control CompletedThis early-phase study tested a new drug combination (ACP-196 plus obinutuzumab) in 69 people with chronic lymphocytic leukemia or related blood cancers. The goal was to see if the combination was safe and could shrink tumors. Participants included both those who had prior treatm…
Phase 1 • Sponsor: Acerta Pharma BV • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Experimental combo shows promise for Tough-to-Treat leukemia
Disease control CompletedThis phase II trial tested a combination of two drugs—MOR00208 (an antibody that targets cancer cells) and lenalidomide (which boosts the immune system)—in 41 people with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or prolymphocytic leukemia (PLL). Some …
Phase 2 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Half-Matched stem cell transplant shows promise for older blood cancer patients
Disease control CompletedThis study tested a stem cell transplant from half-matched (haploidentical) family donors for 34 people with various blood cancers. Patients received a reduced-intensity conditioning regimen of fludarabine, melphalan, and total body irradiation before the transplant. The goal was…
Phase 2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC