Progressive non-fluent aphasia
MONDO:0015059Progressive non-fluent aphasia (PNFA) is a form of frontotemporal dementia (FTD), characterized by agrammatism, laborious speech, alexia, and agraphia, frequently accompanied by apraxia of speech (AOS). Language comprehension is relatively preserved.
Also known as: Agramatic variant of PPA, Agramatic variant of primary progressive aphasia, Primary Progressive Nonfluent aphasia, non-fluent variant PPA, non-fluent primary progressive aphasia
60 clinical trials for this condition and its sub-types, 24 tagged with Progressive non-fluent aphasia itself.
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Sub-types of Progressive non-fluent aphasia
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Semantic dementia 32 trials
1 sub-type
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Could a pill help restore speech in progressive aphasia?
Symptom relief OngoingThis study tests a drug called neflamapimod in 20 people with a language disorder called nonfluent variant primary progressive aphasia (nfvPPA). The goal is to see if the drug is safe and if it can improve language symptoms. Participants will receive either the drug or a placebo …
Phase 2 • Sponsor: EIP Pharma Inc • Aim: Symptom relief
Last updated Jul 08, 2026 00:00 UTC
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Can speech therapy slow language loss in progressive aphasia?
Symptom relief OngoingThis study tests two types of speech therapy for people with primary progressive aphasia, a brain disorder that slowly destroys language skills. Sixty participants will work on word retrieval or script practice with a clinician and at home. Researchers will measure changes in com…
Sponsor: University of Texas at Austin • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Can online speech therapy help those with Dementia-Related language loss?
Symptom relief By invitation onlyThis study tests a speech-language telerehabilitation program for people with primary progressive aphasia (PPA), a dementia that slowly destroys language abilities. The program includes online therapy sessions and care partner training. Researchers will enroll 21 participants to …
Sponsor: University of Texas at Austin • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Scientists map Brain's 'Roads' to predict dementia spread
Knowledge-focused By invitation onlyThis study uses advanced MRI scans and genetic tests to track how neurodegenerative diseases like frontotemporal dementia and ALS spread across the brain's network. Researchers will follow 645 participants, including patients, family members, and healthy controls, for up to 2 yea…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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New study probes brain inflammation to unlock dementia mysteries
Knowledge-focused OngoingThis observational study looks at how brain inflammation contributes to frontotemporal lobar degeneration (FTLD), a group of disorders that cause dementia. Researchers will use advanced brain scans, blood tests, and spinal fluid analysis in 110 participants to find biomarkers tha…
Sponsor: Leiden University Medical Center • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:38 UTC