Progressive bulbar palsy
MONDO:0008890Progressive bulbar palsy involves the brain stem. The brain stem is the part of the brain needed for swallowing, speaking, chewing, and other functions. Signs and symptoms of progressive bulbar palsy include difficulty swallowing, weak jaw and facial muscles, progressive loss of speech, and weakening of the tongue. Additional symptoms include less prominent weakness in the arms and legs, and outbursts of laughing or crying (called emotional lability). Progressive bulbar palsy is considered a variant form of amyotrophic lateral sclerosis (ALS). Many people with progressive bulbar palsy later develop ALS. While there is no cure for progressive bulbar palsy or for ALS, doctors can treat symptoms.
Also known as: Fazio-Londe disease, bulbar palsy, progressive, of childhood, progressive bulbar atrophy
13 clinical trials for this condition and its sub-types.
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Broader categories
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Which feeding route cuts pneumonia risk after stroke?
Disease control CompletedThis trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …
Phase: PHASE4 • Sponsor: Ain Shams University • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
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Neck injection may restore swallowing in stroke survivors
Disease control CompletedThis study tested whether a nerve block called stellate ganglion block can improve swallowing in people with bulbar palsy after an ischemic stroke. 124 participants were randomly assigned to receive either standard rehabilitation alone or standard rehabilitation plus the nerve bl…
Phase: NA • Sponsor: Zeng Xi • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC