Post-traumatic epilepsy
MONDO:0043264Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)
Also known as: post-traumatic epilepsy, Epilepsies, post-traumatic, Epilepsies, traumatic, PTE - post-traumatic epilepsy, concussive convulsion, concussive convulsions, convulsion, concussive, convulsions, concussive
13 clinical trials for this condition and its sub-types.
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Real-World study tracks Epidyolex's Long-Term impact on seizures
Disease control OngoingThis study follows 158 people in France who are prescribed Epidyolex (a cannabidiol-based medicine) for seizures as part of their normal care. Researchers will track how long people stay on the treatment, side effects, seizure frequency, and changes in daily functioning and quali…
Sponsor: Jazz Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New inhaler aims to stop prolonged seizures fast and safely
Symptom relief ENROLLING_BY_INVITATIONThis study tests the long-term safety of an inhaled medication called Staccato alprazolam for people aged 12 and older who have prolonged seizures. About 300 participants will use the inhaler when a seizure starts to see if it stops the seizure quickly and without serious side ef…
Phase: PHASE3 • Sponsor: UCB Biopharma SRL • Aim: Symptom relief
Last updated Aug 16, 2026 00:00 UTC
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Brain injury epilepsy study tests At-Home program to boost memory and ease caregiver burden
Symptom relief OngoingThis study tests a home-based program called HOBSCOTCH-PTE for people with epilepsy caused by a traumatic brain injury. The program aims to improve quality of life, memory, and thinking skills, and also helps support their caregivers. The study includes 160 adults with post-traum…
Phase: NA • Sponsor: Dartmouth-Hitchcock Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Can a brain injury lead to epilepsy? new study aims to find out
Knowledge-focused OngoingThis study follows 300 people who had a traumatic brain injury (TBI) to learn more about the long-term risk of developing epilepsy. Researchers will use interviews, brain scans, blood tests, and EEGs to track changes over time. The goal is to better understand how and why epileps…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC
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Can a brain scan predict epilepsy after a head injury?
Knowledge-focused OngoingThis study looks at 30 people who have had a moderate to severe traumatic brain injury. Researchers use special PET scans to measure inflammation in the brain at two weeks and two months after the injury. The goal is to see if the amount of inflammation is linked to a higher risk…
Phase: PHASE1 • Sponsor: University of California, Davis • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC