Pediatric high-grade glioma
MONDO:1010030A malignant high-grade glioma that occurs during childhood in the central nervous system.
Also known as: childhood malignant glioma, pHGG
3001 clinical trials for this condition and its sub-types, 14 tagged with Pediatric high-grade glioma itself.
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Browse by category →Sub-types of Pediatric high-grade glioma
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New pill combo takes on Hard-to-Treat cancers
Disease control OngoingThis early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …
Phase 1 • Sponsor: Pfizer • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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New drug combo aims to boost Radiation's punch against childhood brain tumors
Disease control OngoingThis study tests a new drug called AZD1390 given alongside radiation therapy for children with aggressive brain tumors (high-grade glioma, DIPG, or DMG). The drug blocks cancer cells from repairing damage caused by radiation, potentially making treatment more effective. About 54 …
Phase 1 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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RNA vaccine fights childhood cancers in new trial
Disease control OngoingThis study tests a new RNA-lipid particle vaccine for children and young adults (ages 3-25) with recurrent high-grade glioma or osteosarcoma that has spread to the lungs. The vaccine is made from the patient's own tumor material and aims to train the immune system to attack the c…
Phase 1/2 • Sponsor: University of Florida • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC