Cure My Disease

Don't miss your cure!

 Log in / Sign up

Pauci-immune glomerulonephritis

MONDO:0019641

Pauci-immune glomerulonephritis (GN) is one of the most frequent causes of rapidly progressive GN (RPGN). It is characterized clinically by renal manifestations of RPGN (hematuria, hypertension) leading to renal failure within days or weeks, and may be associated with manifestations of systemic vasculitis (arthralgia, fever, seizures, mono neuritis and lung involvement). Pauci-immune GN is histologically characterized by focal necrotizing and crescentic GN, with mild or absent glomerular staining for immunoglobulin and complement by fluorescence microscopy, which may manifest either as part of a systemic small vessel vasculitis (including microscopic polyangiitis, granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis), or rarely as part of renal-limited vasculitis (RLV, idiopathic crescentic GN). Immunologic classification is based on the presence or absence of circulating anti-neutrophil cytoplasmic antibodies (ANCAs), namely pauci-immune-GN with ANCA and pauci-immune GN without ANCA.

26 clinical trials for this condition and its sub-types.

Follow this condition — get notified about new trials

Sub-types

Pauci-immune glomerulonephritis with ANCA (3) Pauci-immune glomerulonephritis without ANCA (0)

Broader categories

Disease (618) Inflammatory disease (310) Kidney disorder (202) Urinary system disorder (62) Glomerulonephritis (28) Nephritis (16) Human disease (14) Glomerular disorder (8) Disease by body system or component (0) Disease by developmental or physiological process (0)
Trials to join now! 10 Not yet recruiting 4 Not yet finished but already full! 6 Completed 6
Sort by