Parkinsonian disorder
MONDO:0021095A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
1311 clinical trials for this condition and its sub-types, 67 tagged with Parkinsonian disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Parkinsonian disorder
-
Parkinson disease 1,165 trials · 1,292 incl. sub-types
6 sub-types
- Late-onset Parkinson disease 3 trials · 143 incl. sub-types Sub-types →
- Young-onset Parkinson disease 9 trials · 11 incl. sub-types Sub-types →
- Parkinson disease 16 0 trials
- Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development 0 trials
- Parkinson disease, mitochondrial 0 trials
- Parkinsonian-pyramidal syndrome 0 trials Sub-types →
-
Vascular parkinsonism 4 trials
-
Dystonia 12 2 trials
-
Perry syndrome 0 trials
-
X-linked dystonia-parkinsonism 0 trials
-
Atypical juvenile parkinsonism 0 trials
1 sub-type
- Juvenile onset Parkinson disease 19A 0 trials
-
Cyanide-induced parkinsonism 0 trials
-
Dystonia 16 0 trials
-
Encephalitis lethargica 0 trials
-
Parkinsonism with polyneuropathy 0 trials
-
Parkinsonism-dystonia, infantile 0 trials
3 sub-types
-
Postencephalitic Parkinson disease 0 trials
-
Primary progressive freezing gait 0 trials
Most studied deeper sub-types
-
Daily pill takes aim at a rare brain disease that mimics Parkinson's
Disease control Not yet recruitingResearchers are testing an experimental oral drug called ONO-2808 in adults with the Parkinsonian subtype of multiple system atrophy (MSA-P), a rare and progressive brain disorder. The phase 3 trial enrolls about 486 people in the early stages of the disease, within five years of…
Phase 3 • Sponsor: Ono Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
-
Brain gene therapy aims to boost dopamine in young Parkinson's patients
Disease control Not yet recruitingThis early-stage trial tests a gene therapy called AAV2-hAADC in 9 adults with young-onset Parkinson's disease. The therapy delivers a gene directly to two brain regions (putamen and caudate) to help convert levodopa into dopamine more efficiently. The main goal is to check safet…
Phase 1 • Sponsor: Krzysztof Bankiewicz • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
-
Can a gene therapy rewire brain cells to ease Parkinson's?
Disease control Not yet recruitingThis early trial tests a gene therapy called ZR001 in people with moderately advanced Parkinson's disease. ZR001 is injected into a brain region involved in movement, and a very low dose of an existing drug is then used to activate the therapy. The goal is to see if this approach…
Phase 1 • Sponsor: Qianfoshan Hospital • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
-
Could stem cells ease Parkinson's symptoms? new trial launches
Disease control Not yet recruitingThis study tests two types of stem cell treatments for people with Parkinsonism, a condition that causes movement and non-movement problems. The goal is to see if these treatments are safe and can improve symptoms like tremors, stiffness, and mood changes. About 120 adults aged 4…
Phase 2 • Sponsor: Biocells Medical • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
-
Could zapping the spine steady blood pressure in Parkinson's?
Disease control Not yet recruitingThis study tests whether spinal cord stimulation can help people with Parkinson's disease who experience sudden drops in blood pressure when standing up. Forty participants will receive either an implanted stimulator or a non-invasive version. The goal is to see if the treatment …
Sponsor: Ruijin Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
-
New injection study aims to ease uncontrollable eye blinking
Symptom relief Not yet recruitingThis study tests a botulinum toxin called DaxibotulinumtoxinA (DAXI) for adults with blepharospasm, a condition causing uncontrollable blinking or eye muscle spasms. Twenty participants will receive up to three injection cycles over 12 months. The goal is to measure how long symp…
Phase 2 • Sponsor: University of Pennsylvania • Aim: Symptom relief
Last updated Aug 26, 2026 00:00 UTC
-
Can a new rowing seat help veterans with paralysis row freely?
Symptom relief Not yet recruitingThis trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…
Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jul 26, 2026 00:00 UTC
-
Can a home workout boost brain and body in Parkinson's?
Symptom relief Not yet recruitingThis study tests a 16-week home-based exercise program for people with Parkinson's disease. Fifty participants will either do aerobic and resistance training or just stretching. The goal is to see if the program increases daily physical activity, improves thinking, and enhances q…
Sponsor: University of Illinois at Chicago • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
-
Walking memory tests may reveal early Parkinson's clues
Knowledge-focused Not yet recruitingResearchers are studying whether navigational memory fades before other spatial memory in people with Parkinson's disease and related conditions. The pilot includes 80 participants: those with mild or advanced Parkinson's, those with parkinsonism, and healthy volunteers. Particip…
Sponsor: IRCCS San Raffaele Roma • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
-
New telemedicine approach aims to catch decline in fragile patients early
Knowledge-focused Not yet recruitingThis observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…
Sponsor: Azienda Sanitaria Locale CN2 Alba-Bra • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC