Orofacial cleft
MONDO:0000358A disorder of facial skeleton that is characterized by cleft lip and/or cleft palate that result in feeding, speech and hearing problems caused by failures during development.
70 clinical trials for this condition and its sub-types, 4 tagged with Orofacial cleft itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Orofacial cleft
-
Cleft palate 34 trials · 35 incl. sub-types
9 sub-types
- Isolated cleft palate 3 trials Sub-types →
- Submucosal cleft palate 1 trial
- Kuster syndrome 0 trials
- Rapp-Hodgkin syndrome 0 trials
- Bifid uvula 0 trials
- Cleft hard palate 0 trials
- Cleft palate with or without ankyloglossia, X-linked 0 trials
- Cleft soft palate 0 trials
- Soft and hard cleft palate 0 trials
-
Cleft lip 31 trials
3 sub-types
- Kuster syndrome 0 trials
- Rapp-Hodgkin syndrome 0 trials
- Isolated cleft lip 0 trials Sub-types →
-
Cleft lip/palate 31 trials
4 sub-types
- Orofacial cleft 10 0 trials
- Orofacial cleft 11 0 trials
- Orofacial cleft 15 0 trials
- Orofacial cleft 5 0 trials
-
Cleft lip and alveolus 17 trials
1 sub-type
- Orofacial cleft 5 0 trials
-
Orofacial cleft 1 1 trial
-
GRHL3-related orofacial clefting 0 trials
-
Orofacial cleft 12 0 trials
-
Orofacial cleft 13 0 trials
-
Orofacial cleft 2 0 trials
-
Orofacial cleft 4 0 trials
-
Orofacial cleft 7 0 trials
-
Orofacial cleft 8 0 trials
-
Orofacial cleft 9 0 trials
Most studied deeper sub-types
-
Could skipping opioids make Kids' cleft surgery safer?
Symptom relief Recruiting nowThis study tests whether an opioid-free anesthesia approach using ketamine and dexmedetomidine can control pain and reduce agitation just as well as standard opioid anesthesia in 90 children aged 3 months to 7 years undergoing cleft lip or palate repair. Researchers will measure …
Sponsor: Iva Smiljanić • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
-
Which sedative works best for kids after cleft surgery? new study aims to find out
Symptom relief Recruiting nowThis study compares three different sedatives (ketamine, nalbuphine, and dexmedetomidine) given to 60 children aged 6 months to 3 years who need stitches removed after cleft lip or palate surgery. The goal is to see which drug works fastest and safest to keep the child calm and c…
Sponsor: University Medical Centre Ljubljana • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
-
New DNA mapping technique may reveal hidden causes of cleft lip and palate
Knowledge-focused Recruiting nowThis study aims to find genetic changes that cause orofacial clefts (like cleft lip and palate) but are missed by standard tests. Researchers will use a new, high-resolution DNA mapping method called optical genome mapping on 26 people with clefts who have no known genetic diagno…
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC