Oral cavity cancer
MONDO:0005515A primary or metastatic malignant neoplasm involving the oral cavity. The majority are squamous cell carcinomas.
Also known as: cancer of oral cavity, malignant mouth neoplasm, malignant mouth tumor, malignant mouth tumour, malignant neoplasm of mouth, malignant neoplasm of oral cavity, malignant neoplasm of the mouth, malignant oral cavity neoplasm
3140 clinical trials for this condition and its sub-types, 42 tagged with Oral cavity cancer itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Oral cavity cancer
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Oral cavity carcinoma 16 trials · 202 incl. sub-types
9 sub-types
- Oral cavity squamous cell carcinoma 141 trials · 156 incl. sub-types Sub-types →
- Salivary gland carcinoma 26 trials · 36 incl. sub-types Sub-types →
- Oral cavity carcinoma in situ 5 trials Sub-types →
- Tongue carcinoma 4 trials
- Carcinoma of lip 0 trials · 2 incl. sub-types Sub-types →
- Carcinoma of hard palate 1 trial
- Carcinoma of soft palate 1 trial
- Intraoral basal cell carcinoma 0 trials
- Oral cavity mucoepidermoid carcinoma 0 trials Sub-types →
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Salivary gland cancer 62 trials · 81 incl. sub-types
3 sub-types
- Salivary gland carcinoma 26 trials · 36 incl. sub-types Sub-types →
- Major salivary gland cancer 7 trials · 16 incl. sub-types Sub-types →
- Malignant tumor of minor salivary gland 0 trials Sub-types →
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Tongue cancer 26 trials · 35 incl. sub-types
2 sub-types
- Tongue squamous cell carcinoma 9 trials · 13 incl. sub-types Sub-types →
- Tongue carcinoma 4 trials
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Lip cancer 12 trials · 15 incl. sub-types
3 sub-types
- Carcinoma of lip 0 trials · 2 incl. sub-types Sub-types →
- Lower lip cancer 1 trial
- Upper lip cancer 0 trials
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Cheek mucosa cancer 1 trial · 2 incl. sub-types
1 sub-type
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Gingival cancer 1 trial · 2 incl. sub-types
2 sub-types
- Upper gum cancer 2 trials
- Lower gum cancer 0 trials
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Retromolar area cancer 1 trial
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Hard palate cancer 0 trials · 1 incl. sub-types
1 sub-type
- Carcinoma of hard palate 1 trial
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Soft palate cancer 0 trials · 1 incl. sub-types
2 sub-types
- Carcinoma of soft palate 1 trial
- Uvula cancer 0 trials
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Oral rhabdomyosarcoma 0 trials
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Vestibule of mouth cancer 0 trials
1 sub-type
Most studied deeper sub-types
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New light treatment could fight oral cancer without surgery
Disease control Not yet recruitingThis study tests a low-cost approach to treat pre-cancerous and cancerous mouth lesions using a drug (5-ALA) that makes abnormal cells sensitive to light, followed by laser light delivered through a handheld device. The goal is to destroy these lesions without surgery. The trial …
Phase 2 • Sponsor: University of Massachusetts, Boston • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Could a simple pill before surgery beat back head and neck cancer?
Disease control Not yet recruitingThis study tests whether taking a short course of capecitabine pills before surgery can shrink tumors and improve outcomes for people with HPV-negative head and neck cancer. About 75 adults with stage III or IVa cancer will be randomly assigned to either standard care or capecita…
Phase 2 • Sponsor: Sir Mortimer B. Davis - Jewish General Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Can a new tracer reveal hidden tumors?
Diagnosis Not yet recruitingThis trial is testing two new imaging tracers, called CM500, to see if they can help detect solid tumors anywhere in the body. The tracers are given by injection and then used with PET scans to create detailed images. The study includes healthy volunteers and people with various …
Early phase 1 • Sponsor: Lumina Pharmaceuticals Inc • Aim: Diagnosis
Last updated Aug 30, 2026 00:00 UTC
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Can light be the new shield against radiation mouth sores?
Prevention Not yet recruitingThis pilot study tests two light therapy devices—one placed inside the mouth and one outside—to prevent and treat painful mouth sores caused by radiation therapy. Sixty adults with oral cavity or oropharynx cancer will receive light sessions twice a week for prevention, then thre…
Sponsor: Centre Paul Strauss • Aim: Prevention
Last updated Jun 27, 2026 13:02 UTC
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Mouth spray may stop radiation burns in cancer patients
Prevention Not yet recruitingThis study tests if a spray called Kangfu Spray can prevent severe mouth sores in people with oral cancer who are getting radiation therapy. About 140 participants will either get the spray plus standard mouth care, or standard care alone. The goal is to see if the spray reduces …
Sponsor: YE ZHANG • Aim: Prevention
Last updated Jun 27, 2026 12:10 UTC
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Dye technique could spare neck surgery for head and neck cancer patients
Knowledge-focused Not yet recruitingThis study tests whether injecting two dyes around the tumor and into cancerous lymph nodes can help surgeons spot hidden cancer spread in head and neck cancer. Twenty adults with oral cavity or head and neck skin cancer will receive the dyes before surgery. The goal is to see if…
Phase 2 • Sponsor: Centre Hospitalier Universitaire Vaudois • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC