Oculocerebrorenal syndrome
MONDO:0010645Oculocerebrorenal syndrome of Lowe (OCRL) is a multisystem disorder characterized by congenital cataracts, glaucoma, intellectual disabilities, postnatal growth retardation and renal tubular dysfunction with chronic renal failure.
Also known as: Lowe disease, Lowe oculo-cerebro-renal syndrome, Lowe oculocerebrorenal syndrome, Lowe syndrome, Lowe syndrome, X-linked recessive, OCR, OCRL, oculo-cerebro-renal dystrophy
4 clinical trials for this condition and its sub-types.
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Could a diabetes drug protect kidneys in children with genetic disease?
Disease control Recruiting nowThis study tests whether adding dapagliflozin (a diabetes drug) to standard care reduces protein leakage in the urine of children with hereditary kidney diseases. About 44 children will receive either dapagliflozin plus standard care or standard care alone for 12 weeks, then swit…
Phase: PHASE3 • Sponsor: Children's Hospital of Fudan University • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Can blood and urine markers reveal how rare kidney diseases progress?
Knowledge-focused Recruiting nowThis study follows people with rare inherited forms of kidney stones and chronic kidney disease, such as primary hyperoxaluria, cystinuria, and Dent disease, to learn how these conditions develop over time. Researchers will measure markers of inflammation in blood and urine and t…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC