Nodular cutaneous amyloidosis
MONDO:0015302Primary localized cutaneous nodular amyloidosis (PLCNA) is the most rare form of primary cutaneous amyloidosis, a skin disease characterized by the accumulation of amyloid deposits in the dermis, characterized clinically by yellowish waxy crusted nodules and papules on the face, lower extremities, trunk, scalp, and genitalia and histologically by the localized deposition of immunoglobulin-derived amyloid in the papillary dermis and subcutis. PLCNA can be associated with connective tissue disorders such as SjC6grenBs syndrome and CREST syndrome.
Also known as: PLCNA, amyloidosis nodular localised cutaneous, amyloidosis nodular localized cutaneous, primary localised cutaneous nodular amyloidosis, primary localized cutaneous nodular amyloidosis, NLCA, amyloidosis cutis nodularis atrophicans
3 clinical trials for this condition and its sub-types.
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App-Based diet tracking tested in rare disease
Knowledge-focused Recruiting nowThis pilot trial is testing whether amyloidosis patients can use the MyFitnessPal smartphone app to track their daily food and supplement intake for 8 weeks. The goal is to see if this low-cost method is feasible for studying malnutrition and weight loss in this condition. Forty …
Phase: NA • Sponsor: Barbara Ann Karmanos Cancer Institute • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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New biobank aims to unlock secrets of rare amyloidosis
Knowledge-focused Recruiting nowThis study is creating a biobank and data registry for people with amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect blood, urine, tissue samples, and medical information from 505 participants over time. The goal is to store these ma…
Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Scientists launch massive amyloid sample collection
Knowledge-focused Recruiting nowThis study is creating a large collection of blood, urine, and tissue samples from up to 10,000 people with amyloid diseases (like multiple myeloma). The goal is to store these samples and health data for future research to better understand these conditions. Participants do not …
Sponsor: Boston Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC