Neural tube defect
MONDO:0018075A congenital defect characterized by failure of the neural tube to close completely; this results in the presence of openings in the brain or spinal cord. Examples of neural tube defects include encephalocele and spina bifida.
Also known as: NTD, spinal dysraphism
24 clinical trials for this condition and its sub-types.
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Broader categories
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Womb surgery breakthrough: two methods to fix spina bifida before birth
Disease control OngoingThis study tests two ways to surgically repair spina bifida in the womb using a tiny camera. The goal is to close the spinal defect and reverse brain changes caused by the condition. About 110 pregnant women carrying babies with spina bifida will take part. The two methods are co…
Phase: NA • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Keyhole surgery in the womb could fix spina bifida with fewer risks
Disease control OngoingThis study tests a minimally invasive fetoscopic surgery to repair spina bifida in unborn babies. The goal is to close the spinal defect and reverse brain herniation while reducing risks like uterine rupture and preterm birth that come with open fetal surgery. Thirty pregnant wom…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Patch may boost fetal spina bifida repair, early trial hints
Disease control OngoingThis study tests two minimally invasive fetal surgery techniques for repairing neural tube defects (spina bifida) in the womb. One method uses a Durepair patch to reinforce the repair, while the other does not. Researchers aim to see if the patch leads to a thicker repair and few…
Phase: PHASE1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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MRI study reveals how neck position impacts brain fluid flow
Knowledge-focused ENROLLING_BY_INVITATIONThis study uses MRI scans to understand how different neck positions affect the flow of cerebrospinal fluid (the fluid around the brain and spine) in people with Chiari malformations and similar neck abnormalities. Researchers will compare fluid flow in healthy volunteers and pat…
Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC