Multiple system atrophy

This trial is investigating whether ATH434, an experimental drug taken twice daily as a tablet, can help control multiple system atrophy (MSA), a rare and progressive brain disorder. The study enrolls people who have already completed a prior phase 2 trial of ATH434 and may benef…

This early-stage study tests whether injecting special stem cells into the brain is safe for people with a rare, severe movement disorder called MSA-P. Only 3 participants will receive the treatment, and the main goal is to check for serious side effects within the first month. T…

This early-stage study tests a new drug, ALT001, in 20 people with a rare brain disease called multiple system atrophy-cerebellar type (MSA-C). The main goal is to check if the drug is safe and tolerable. Researchers will also look for early signs that it might help control the d…

This early-phase trial tests a drug called ALT001, a nerve repair protein, in 60 people with multiple system atrophy (MSA), a rare and progressive brain disorder. The study is open-label, meaning everyone knows they are getting the drug, and it focuses on safety and whether the d…

This study tests whether a person's own stem cells, processed and given by IV, can safely help with multiple system atrophy (MSA) — a rare, worsening brain disease that affects movement and automatic body functions like blood pressure. Fifty adults aged 35 to 65 will receive eith…

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study will test a new intelligent diagnostic system for orthostatic hypotension (a sudden drop in blood pressure when standing up). The system continuously monitors blood pressure, brain blood flow, and heart signals to classify the condition more precisely. Researchers plan…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This study tests whether butylphthalide, a drug used for stroke, can improve symptoms of Multiple System Atrophy (MSA), a rare and serious brain disorder. About 150 adults with MSA will take either the drug or a placebo three times a day for six months. Researchers will track sym…

This observational study tests whether wearable sensors and digital health tools can reliably measure falls, movement, speech, and thinking skills in people with progressive supranuclear palsy, Parkinson's disease, or multiple system atrophy. Participants wear a pendant sensor an…

This study from Stanford University will look at how people react when they learn their Lewy Body Disease biomarker test results. Researchers will interview and survey 40 participants, both with and without symptoms, to measure distress and other responses over time. The goal is …

This observational study will enroll 200 people—100 with Parkinson's disease, 50 with related conditions, and 50 healthy controls—to find molecular markers in blood, urine, and stool that can distinguish Parkinson's from atypical parkinsonism. Participants provide samples and und…