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Melorheostosis

MONDO:0007970

Melorheostosis is a rare connective tissue disorder characterized by a sclerosing bone dysplasia, usually limited to one side of the body (rarely bilateral), that manifests with pain, stiffness, joint contractures and deformities.

Also known as: melorheostosis, isolated, somatic mosaic, Mel, melorheostosis, isolated

3 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Musculoskeletal system disorder (207) Hereditary disease (176) Bone disorder (51) Human disease (14) Osteopetrosis (6) Bone remodeling disease (5) Skeletal system disorder (4) Disease of genetic or genomic mechanism (2) Osteosclerosis (1)

Trials to join now! 1 Not yet finished but already full! 1 Completed 1

Rare bone disease patient tries exercise therapy — early results promising?

Symptom relief Ongoing

This study looks at whether a structured physiotherapy and exercise program can improve pain, strength, balance, and quality of life in one person with melorheostosis, a rare bone condition. The patient will do exercises three times a week for eight weeks, along with education ab…

Phase: NA • Sponsor: Yeditepe University • Aim: Symptom relief

Last updated Jun 28, 2026 00:00 UTC