Medulloblastoma
MONDO:0007959A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity.
Also known as: cerebellum embryonal neoplasm, medulloblastoma, medulloblastoma, autosomal recessive, autosomal dominant, somatic mutation, medulloblastoma, desmoplastic, autosomal recessive, autosomal dominant, somatic mutation, medulloblastoma, malignant, medulloblastoma, somatic, medulloblastomas, CNS PNET
1603 clinical trials for this condition and its sub-types, 110 tagged with Medulloblastoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Medulloblastoma
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Childhood medulloblastoma 14 trials
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Medulloblastoma non-WNT/non-SHH 1 trial · 4 incl. sub-types
2 sub-types
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Medulloblastoma SHH activated 3 trials
2 sub-types
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Adult medulloblastoma 1 trial
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Medulloblastoma WNT activated 1 trial
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Brain stem medulloblastoma 0 trials
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Classic medulloblastoma 0 trials
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Desmoplastic/nodular medulloblastoma 0 trials
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Large cell medulloblastoma 0 trials
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Melanotic medulloblastoma 0 trials
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New proton therapy spares spine growth in kids with brain cancer
Disease control Not yet recruitingThis study looks at a new way to give radiation to children with brain tumors that need whole-brain and whole-spine treatment. The technique, called vertebral body-sparing proton therapy, aims to protect the front of the spine bones to preserve bone marrow and growth. Researchers…
Sponsor: Ruijin Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Brain tumor trial aims to find kinder chemo for toddlers
Disease control Not yet recruitingThis phase 3 trial compares two standard chemotherapy regimens for children under 5 with a low-risk type of medulloblastoma. The main goal is to see which approach better protects thinking and learning skills 2.5 years after diagnosis. The study will also track survival and side …
Phase 3 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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AI reads MRI scans to reveal hidden brain tumor types in children before surgery
Diagnosis Not yet recruitingThis study is developing an artificial intelligence (AI) system that can analyze standard MRI brain scans to determine the specific molecular subtype of a child's brain tumor before surgery. The research includes 1,400 children under 18 with suspected brain tumors, using both pas…
Sponsor: Huashan Hospital • Aim: Diagnosis
Last updated Jul 25, 2026 00:00 UTC
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Custom 3D-Printed stents could spare kids with brain cancer from painful mouth sores
Symptom relief Not yet recruitingThis trial tests whether custom 3D-printed intraoral stents can protect the mouth from radiation damage in children with medulloblastoma, a type of brain cancer. During radiotherapy, the stent is worn inside the mouth to physically move healthy tissue away from the radiation beam…
Sponsor: Ain Shams University • Aim: Symptom relief
Last updated Jul 23, 2026 00:00 UTC
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Scientists probe MYC gene's weak spots in aggressive childhood brain cancer
Knowledge-focused Not yet recruitingThis study investigates the most aggressive form of medulloblastoma, a common childhood brain tumor, focusing on tumors with high MYC gene activity. Researchers will analyze tumor tissue collected during standard surgery and grow 3D tumor models in the lab to understand how MYC d…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jul 12, 2026 00:00 UTC
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Personalized drug test aims to outsmart refractory brain tumors
Knowledge-focused Not yet recruitingThis study tests a lab technique called pharmacoscopy that analyzes a patient's tumor tissue to find which drugs might work best for them. It includes 40 adults with various aggressive or rare brain tumors that have not responded to standard treatments. The main goal is to see if…
Phase 2 • Sponsor: University of Zurich • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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New app guides young cancer survivors through life after treatment
Knowledge-focused Not yet recruitingThis study is testing a mobile app called my.naviGATE for teens and young adults (ages 15-24) who have finished cancer treatment. The app provides personalized education, peer support, and tracks how patients are doing. Researchers want to see if the app helps patients feel more …
Sponsor: Dana-Farber Cancer Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC