Malignant germ cell tumor
MONDO:0006290A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma.
Also known as: cancer of germ cell, germ cell cancer, germ cell tumor, malignant, malignant germ cell neoplasm, malignant germ cell tumor, malignant neoplasm of germ cell, malignant neoplasm of the germ cell, malignant tumor of germ cell
2802 clinical trials for this condition and its sub-types, 15 tagged with Malignant germ cell tumor itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Malignant germ cell tumor
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Malignant testicular germ cell tumor 14 trials · 36 incl. sub-types
6 sub-types
- Testis refractory cancer 13 trials
- Testicular seminoma 8 trials Sub-types →
- Testicular non-seminomatous germ cell cancer 3 trials · 4 incl. sub-types Sub-types →
- Mixed testicular germ cell cancer 2 trials Sub-types →
- Malignant teratoma of testis 0 trials
- Testis polyembryoma 0 trials
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Seminoma 22 trials
2 sub-types
- Testicular seminoma 8 trials Sub-types →
- Extragonadal seminoma 1 trial Sub-types →
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Extragonadal germ cell cancer 0 trials · 22 incl. sub-types
9 sub-types
- Extragonadal nonseminomatous germ cell tumor 5 trials · 19 incl. sub-types Sub-types →
- Extragonadal germinoma 0 trials · 4 incl. sub-types Sub-types →
- Malignant pineal area germ cell neoplasm 2 trials · 3 incl. sub-types Sub-types →
- Extragonadal seminoma 1 trial Sub-types →
- Mediastinal malignant germ cell tumor 1 trial Sub-types →
- Malignant cardiac germ cell tumor 0 trials
- Malignant gastric germ cell tumor 0 trials Sub-types →
- Malignant peritoneal germ cell tumor 0 trials
- Mixed extragonadal germ cell cancer 0 trials Sub-types →
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Germinoma 7 trials · 9 incl. sub-types
1 sub-type
- Extragonadal germinoma 0 trials · 4 incl. sub-types Sub-types →
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Mixed germ cell tumor 3 trials · 5 incl. sub-types
6 sub-types
- Mixed testicular germ cell cancer 2 trials Sub-types →
- Mixed extragonadal germ cell cancer 0 trials Sub-types →
- Mixed germ cell tumor of vulva 0 trials
- Mixed teratoma and seminoma 0 trials
- Ovarian mixed germ cell neoplasm 0 trials
- Teratocarcinoma 0 trials
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Malignant germ cell tumor of ovary 2 trials · 4 incl. sub-types
4 sub-types
- Ovarian primitive germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Choriocarcinoma of ovary 1 trial Sub-types →
- Malignant dysgerminomatous germ cell tumor of ovary 0 trials
- Primary non-gestational choriocarcinoma of ovary 0 trials
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Malignant teratoma 1 trial · 3 incl. sub-types
7 sub-types
- Immature ovarian teratoma 1 trial · 2 incl. sub-types Sub-types →
- Pineal region immature teratoma 1 trial
- Immature extragonadal teratoma 0 trials
- Immature gastric teratoma 0 trials
- Intermediate malignant teratoma 0 trials
- Malignant teratoma of mediastinum 0 trials
- Malignant teratoma of testis 0 trials
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Malignant childhood germ cell neoplasm 0 trials · 3 incl. sub-types
12 sub-types
- Childhood central nervous system germinoma 1 trial Sub-types →
- Childhood endodermal sinus tumor 0 trials · 1 incl. sub-types Sub-types →
- Childhood immature teratoma of ovary 1 trial
- Childhood central nervous system embryonal carcinoma 0 trials
- Childhood central nervous system mixed germ cell tumor 0 trials
- Childhood choriocarcinoma of the ovary 0 trials
- Childhood embryonal testis carcinoma 0 trials
- Childhood ovarian embryonal carcinoma 0 trials
- Childhood testicular choriocarcinoma 0 trials
- Childhood testicular mixed germ cell cancer 0 trials Sub-types →
- Pediatric CNS choriocarcinoma 0 trials
- Pediatric ovarian dysgerminoma 0 trials
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Dysgerminoma 1 trial
2 sub-types
- Dysgerminoma of ovary 0 trials Sub-types →
- Pineal region dysgerminoma 0 trials
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1 sub-type
- Uterine corpus choriocarcinoma 0 trials
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Pulmonary artery choriocarcinoma 0 trials
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Vaginal germ cell malignant tumor 0 trials
1 sub-type
- Vaginal yolk sac tumor 0 trials
Most studied deeper sub-types
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Major trial tests gentler chemo for germ cell tumors
Disease control Recruiting nowThis phase 3 trial studies two approaches for germ cell tumors. For low-risk patients whose tumor has been removed, doctors will monitor them closely instead of giving chemotherapy. For standard-risk patients whose cancer has spread, the trial compares two chemotherapy drugs—carb…
Phase 3 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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New biologic drug DBC-664 takes aim at Hard-to-Treat cancers
Disease control Recruiting nowThis early-phase trial is testing an experimental biologic drug, DBC-664, in adults with advanced solid tumors such as ovarian, lung, and stomach cancers that have spread or come back. The study has two parts: first, finding a safe dose, and then expanding to see how well the dru…
Phase 1 • Sponsor: Duboce Biopharmaceuticals, Inc. • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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New hope for kids with tough cancers: Two-Drug attack on tumors
Disease control Recruiting nowThis study is for children and young adults (ages 1 to 30) whose solid tumors have come back or not gone away with standard treatment. It tests two different drug pairs: one combines Onivyde with talazoparib, the other Onivyde with temozolomide. Both work by damaging cancer cell …
Phase 1/2 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Simple blood test could spot hidden germ cell cancer
Diagnosis Recruiting nowThis study is testing whether a blood test that looks for tumor DNA can find leftover cancer cells in people with germ cell tumors (a type of testicular or ovarian cancer). Researchers will enroll 130 patients with stage I, II, or III disease and check how well the test works aft…
Sponsor: Indiana University • Aim: Diagnosis
Last updated Jun 27, 2026 14:00 UTC
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Can a simple injection save your hearing during cancer treatment?
Symptom relief Recruiting nowThis early-stage trial tests whether adding Pedmark to standard cisplatin chemotherapy can prevent hearing loss in men with metastatic testicular cancer. About 80% of patients currently develop hearing damage from cisplatin. Pedmark works by neutralizing harmful molecules that ca…
Phase 1 • Sponsor: City of Hope Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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New study tracks memory loss in kids after brain radiation
Knowledge-focused Recruiting nowThis study looks at how radiation to the brain affects memory in children who had a brain tumor. Researchers will test memory and thinking skills in 130 children ages 4 to 12, starting 2 years after radiation and again 2 years later. The goal is to learn which parts of the brain …
Sponsor: Institut Claudius Regaud • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC