Lipodermatosclerosis

MONDO:0023646

Lipodermatosclerosis refers to changes in the skin of the lower legs. It is a form of panniculitis (inflammation of the layer of fat under the skin). Signs and symptoms include pain, hardening of skin, change in skin color (redness), swelling, and a tapering of the legs above the ankles. The exact underlying cause is unknown; however, it appears to be associated with venous insufficiency and/or obesity. Treatment usually includes compression therapy.

Also known as: acute lipodermatosclerosis, hypodermitis sclerodermaformis, sclerosing panniculitis

81 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Inflammatory disease (310) Autoimmune disease (283) Immune system disorder (140) Skin disorder (123) Rheumatic disorder (80) Connective tissue disorder (67) Dermatitis (57) Scleroderma (45) Human disease (14)

Trials to join now! 32 Not yet recruiting 8 Not yet finished but already full! 13 Completed 27 Terminated 1

Biopsy tolerance study ends early – what we know

Knowledge-focused Terminated

This study aimed to understand how well patients tolerate biopsies for autoimmune diseases and whether they feel properly informed. It planned to enroll 505 people but was terminated early. The results may help improve patient experience with these common procedures.

Sponsor: University Hospital, Brest • Aim: Knowledge-focused

Last updated Jun 28, 2026 00:00 UTC

Lipodermatosclerosis

Broader categories

Biopsy tolerance study ends early – what we know