Lennox-Gastaut syndrome
MONDO:0016532Lennox-Gastaut syndrome (LGS) belongs to the group of severe childhood epileptic encephalopathies.
Also known as: LGS, encephalopathy of childhood, epileptic encephalopathy Lennox-Gastaut type, macrocephaly and epileptic encephalopathy
40 clinical trials for this condition and its sub-types, 26 tagged with Lennox-Gastaut syndrome itself.
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Sub-types of Lennox-Gastaut syndrome
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New drug shows promise for rare, severe childhood epilepsy
Disease control Recruiting nowThis study tests whether clemizole HCl (EPX-100) can safely reduce seizures when added to current treatments for Lennox-Gastaut syndrome, a severe form of epilepsy. About 260 children and adults aged 2 to 55 will receive either the drug or a placebo. The main goal is to measure c…
Phase 3 • Sponsor: Epygenix • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Which treatment tames LGS seizures better: surgery or more meds?
Disease control Recruiting nowThis study looks at two ways to treat Lennox-Gastaut syndrome (LGS), a severe form of childhood epilepsy: adding more anti-seizure medications or undergoing palliative surgery (like a vagus nerve stimulator or corpus callosotomy). Researchers will track thousands of children acro…
Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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Lifeline for kids with severe epilepsy: drug access extended
Disease control Expanded accessThis program offers continued access to rufinamide for children with Lennox-Gastaut syndrome, a severe form of epilepsy, who completed a previous study. The goal is to keep providing the medication until it becomes commercially available in Poland. Only children who were already …
Sponsor: Eisai Inc. • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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Brain pacemaker trial aims to cut seizures in kids with severe epilepsy
Disease control Recruiting nowThis study tests whether deep brain stimulation (DBS) can safely reduce seizures in children aged 5-14 with Lennox-Gastaut syndrome, a severe form of epilepsy. The trial uses a special device called Picostim to send electrical pulses to the brain. Researchers will track seizure f…
Sponsor: University College, London • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC