Legg-Calve-Perthes disease
MONDO:0007885A hip region disease that is characterized by uni- or bilateral avascular necrosis (AVN) of the femoral head in children. In a small percentage of cases, mutations in the COL2A1 gene were found to be responsible.
Also known as: Legg Calvé Perthes Disease, Legg-CALVE-Perthes disease, Legg-Calve-Perthes disease, Legg-Calve-Perthes symptom, Legg-Calve-Perthes syndrome, Legg-Calvé-Perthes disease, Legg-Perthes disease, Osteochondrosis of the capital femoral epiphysis
10 clinical trials for this condition and its sub-types.
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Stem cells and oxygen therapy may save hips from collapse
Disease control CompletedThis study tested a triple therapy—surgery, stem cells, and hyperbaric oxygen—in 24 patients with early-stage osteonecrosis (bone death) of the hip. After two years, patients reported better hip function and fewer needed a hip replacement. The approach aims to stop the bone from …
Sponsor: Ankara City Hospital Bilkent • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New drug RAB001 takes first step: safety check in healthy volunteers
Knowledge-focused CompletedThis early-stage study tested the safety and tolerability of a new drug called RAB001 in 16 healthy adults. Researchers gave single and multiple injections at two dose levels to see how the body handles the drug and if it causes side effects. This is a first step before testing t…
Phase: PHASE1 • Sponsor: ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC