Laryngeal disorder

This study tested an experimental drug called ENV-101 (taladegib) in 20 adults with advanced solid tumors that have a specific genetic mutation (PTCH1 loss-of-function). The drug works by blocking a growth pathway in cancer cells. Researchers measured how many patients' tumors sh…

This early-phase study tested a special artificial larynx with valves in 10 adults who had severe swallowing troubles, often after throat cancer. The goal was to see if the device could help them swallow safely and possibly allow them to close their tracheotomy tube. The study fo…

This early-phase trial tested whether adding the immunotherapy drug pembrolizumab to standard chemoradiation is safe and effective for people with advanced head and neck cancer. 59 participants received pembrolizumab before, during, and after their regular treatment. The goal was…

This study tested two drugs used to reverse muscle relaxants after surgery: sugammadex and a combination of neostigmine and glycopyrrolate. The goal was to see which one better prevents urinary retention in 124 patients having ear, nose, or throat surgery who were at high risk du…

This study looked at two ways to help patients breathe during throat surgery: a newer method called flow-controlled ventilation and a standard method. Researchers measured how well each method worked in 71 adults having elective throat surgery. The goal was to see if the newer me…

This study looked at how using high-flow nasal oxygen during laryngeal surgery affects the heart and blood vessels. Twenty relatively healthy adults were monitored for changes in heart function compared to standard breathing support. The goal was to understand potential risks, no…

This completed study tested two ways of helping patients breathe during microscopic throat surgery. One method uses a steady airflow, while the other uses a set volume of air. The goal was to see which method keeps airway pressure lower and safer. 68 adults having elective laser …

This study tested whether a mathematical model could help doctors choose the best radiation schedule for people with HPV-positive throat cancer. The goal was to see if personalized dosing could shrink tumors faster than standard treatment. Fifty-five adults took part, and researc…

This study collected tumor samples from 419 people with head and neck cancer to create a biobank. Researchers will use these samples in future genomic studies to find factors that predict how well a person will respond to treatment. The goal is to improve personalized outcome pre…