LAMB2-related infantile-onset nephrotic syndrome
MONDO:0013621LAMB2-related infantile-onset nephrotic syndrome is a rare primary glomerular disease due to homozygous mutations in LAMB2 gene, characterized by prenatal or early-onset progressive steroid-resistant nephrotic syndrome leading to renal failure, and variable ocular defects including myopia, fundus abnormalities, strabismus or nystagmus, without severe visual impairment or blindness. Patients present in early infancy with massive proteinuria, edema, hypertension, and hyperlipidemia. Psychomotor development is normal.
Also known as: mesangial sclerosis, diffuse renal, with ocular abnormalities, NPHS5, nephrotic syndrome, type 5, with or without ocular abnormalities
4 clinical trials for this condition and its sub-types, 0 tagged with LAMB2-related infantile-onset nephrotic syndrome itself.
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Browse by category →Sub-types of LAMB2-related infantile-onset nephrotic syndrome
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Pierson syndrome 0 trials
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Could a diabetes drug protect kidneys in children with genetic disease?
Disease control Recruiting nowThis study tests whether adding dapagliflozin (a diabetes drug) to standard care reduces protein leakage in the urine of children with hereditary kidney diseases. About 44 children will receive either dapagliflozin plus standard care or standard care alone for 12 weeks, then swit…
Phase 3 • Sponsor: Children's Hospital of Fudan University • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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China launches massive kidney registry to map nephrotic syndrome
Knowledge-focused Recruiting nowResearchers at Sun Yat-sen University are building a registry of people with nephrotic syndrome across hospitals in China. The study aims to enroll 5,000 patients regardless of the underlying cause. By recording baseline and follow-up information, the team will track kidney funct…
Sponsor: Sun Yat-sen University • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Personalized trial matching could revolutionize kidney disease treatment
Knowledge-focused Recruiting nowThis study helps people with certain kidney diseases (like nephrotic syndrome and FSGS) find clinical trials that match their specific disease profile. Researchers analyze participants' molecular data to recommend targeted therapies in ongoing trials. The goal is to improve treat…
Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Scientists hunt for hidden antibodies in Kids' kidney disease
Knowledge-focused Recruiting nowThis study is investigating whether certain autoantibodies, especially those targeting a protein called nephrin, play a role in nephrotic syndrome, a kidney condition that causes swelling and protein loss in urine. Researchers will analyze blood and kidney tissue from 50 children…
Sponsor: Meyer Children's Hospital IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC