Intraepithelial neoplasia

This study tests a new 15-valent HPV vaccine to see if it is safe and triggers a strong immune response. It involves 330 healthy Chinese volunteers aged 9 to 45. Participants will receive three doses of the vaccine or a placebo, and researchers will monitor side effects and measu…

This study looks at the best way to treat people with p53-mutant oral dysplasia (abnormal cells in the mouth) and early-stage oral cancer. About 636 adults will be placed into three groups based on their diagnosis and receive either monitoring, surgery, or surgery plus neck disse…

This study tests if a cream called imiquimod can treat pre-cancerous spots in the mouth. Twenty adults with these spots will apply the cream and get two follow-up biopsies. The goal is to see if the spots shrink and if the abnormal cells become less severe.

This phase 2 trial tests whether APG-157, a plant-based pastille taken three times daily, can shrink or eliminate precancerous growths in the mouth. Researchers will enroll 32 adults with moderate to severe oral dysplasia or carcinoma in situ. The goal is to see if the treatment …

This study tests a new imaging device called the Active Biopsy Guidance System to help doctors decide when and where to take tissue samples (biopsies) from mouth lesions. About 90 adults with suspicious mouth spots or a history of oral cancer will participate. The goal is to see …

This study tests an artificial intelligence system that assists doctors in determining how deep early esophageal cancer has spread, using endoscopic ultrasound images. The goal is to improve the accuracy of preoperative staging, which helps guide treatment decisions. Researchers …

This study looks at whether the presence and distribution of H. pylori bacteria in the stomach, along with tissue features of early gastric cancer, can help predict how the cancer will behave and what the long-term outlook may be. Researchers will analyze data from about 1,500 pe…

This study is for 1000 people with oral cancer or precancerous mouth lesions. Researchers will collect tissue samples and ask participants about their symptoms before, during, and after treatment. The goal is to find better ways to predict how the disease will behave and which tr…

The PREDICT study is creating a registry and biospecimen bank for people with pancreatic disease or at high risk for pancreatic cancer. Researchers will collect blood, tissue, urine, and other samples from 1,000 participants to study the causes and biology of the disease. This is…

This research study collects sputum and tissue samples from 700 people with precancerous changes or certain cancers (lung, head and neck, esophageal). The goal is to find biomarkers—biological signs—that could help understand or detect these cancers earlier. Participants include …