Could a simple pastille stop mouth cancer before it starts?
NCT ID NCT05865028
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether APG-157, a plant-based pastille taken three times daily, can shrink or eliminate precancerous growths in the mouth. Researchers will enroll 32 adults with moderate to severe oral dysplasia or carcinoma in situ. The goal is to see if the treatment reduces lesion size and improves tissue health over up to three 4-week cycles.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
APG-157 (a plant-based compound taken as a pastille)
What this could lead to
If it works, this could point toward a non-surgical treatment for precancerous mouth lesions, potentially preventing oral cancer.
What could go wrong
This is a small early-phase trial with only 32 people, so results may not apply broadly. The treatment may not shrink lesions or could cause side effects.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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