Immune reconstitution inflammatory syndrome
MONDO:0100185An inflammatory condition that arises after initiating antiretroviral therapy (ART) therapy in HIV-infected patients that results from restored immunity to specific infectious or non-infectious antigens.
Also known as: IRD, IRIS, IRS, immune reconstitution syndrome, immune restoration disease, immune reconstitution inflammatory syndrome associated with Kaposi sarcoma
27 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
New drug aims to fix Immunotherapy's blood problems in lung cancer
Disease control Not yet recruitingThis phase 2 trial tests the drug golidocitinib in 16 people with advanced lung cancer who have severe blood problems caused by immunotherapy. The goal is to see if the drug can safely improve blood counts and reduce symptoms. Participants take the drug until their blood levels r…
Phase: PHASE2 • Sponsor: The First Affiliated Hospital of Guangzhou Medical University • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
-
Could a common steroid prevent a deadly complication in AIDS patients?
Prevention Not yet recruitingThis study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…
Phase: NA • Sponsor: Shanghai Public Health Clinical Center • Aim: Prevention
Last updated Jun 27, 2026 12:29 UTC
-
Common nausea pill may tame immunotherapy's harsh side effects in liver cancer
Symptom relief Not yet recruitingThis study tests whether ondansetron, a drug typically used for nausea, can lower the risk and severity of side effects from immunotherapy in people with liver cancer. About 134 patients will receive ondansetron alongside their standard cancer treatment. The goal is to see if thi…
Phase: PHASE2 • Sponsor: First Affiliated Hospital of Wenzhou Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
-
30,000 blood samples could revolutionize rapid disease testing
Knowledge-focused Not yet recruitingThis study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…
Sponsor: LumiraDx UK Limited • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC