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Idiopathic malabsorption due to bile acid synthesis defects

MONDO:0019393

Idiopathic malabsorption due to increased acid bile synthesis is an intestinal disease of unknown etiology characterized by an overproduction of bile acids which leads to chronic watery diarrhea.

Also known as: idiopathic bile acid malabsorption

6 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Metabolic disease (233) Inherited lipid metabolism disorder (189) Hereditary disease (176) Digestive system disorder (160) Intestinal disorder (66) Inborn errors of metabolism (45) Human disease (14) Malabsorption syndrome (11) Disease of genetic or genomic mechanism (2)

Trials to join now! 3 Not yet finished but already full! 2 Completed 1

Could a probiotic ease chronic diarrhea? mayo clinic investigates

Disease control Completed

This study tests whether a high-dose probiotic (De Simone formulation) can lower bile acid levels in stool and improve diarrhea in people with bile acid malabsorption. Twenty-four adults will take the probiotic or a placebo for about three weeks. Researchers will measure changes …

Phase: NA • Sponsor: Mayo Clinic • Aim: Disease control

Last updated Aug 05, 2026 00:00 UTC