Hypospadias
MONDO:0005345Hypospadias is the displacement of the urethral meatus on the ventrum of the penis. This abnormality is associated with a varyingly bent, twisted penis and opened dorsal prepuce.
Also known as: hypospadias, hypospadias (disease), hypospadias familial
35 clinical trials for this condition and its sub-types.
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Broader categories
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Can a single drug dose make repeat hypospadias surgery safer?
Disease control OngoingThis trial tests whether a single intravenous dose of tranexamic acid, a drug that helps blood clot, can reduce bleeding during repeat hypospadias repair in boys aged 1 to 10 years. Half the children will receive the drug, and half will receive a placebo (salt water). The study m…
Sponsor: Aswan University Hospital • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Could a saline rinse stop infections after penile surgery?
Disease control OngoingThis study tests whether rinsing the urethral stent with salt water after hypospadias surgery can prevent wound infections in teenage boys. About 150 adolescents will be randomly assigned to get either the rinse plus standard drainage or drainage alone. The goal is to see if this…
Sponsor: Xing Liu • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Reading the genetic code to understand differences in sex development
Knowledge-focused By invitation onlyThis study aims to find genetic causes of conditions that affect the development of the gonads and genitals, such as hypospadias and ambiguous genitalia. Researchers will use whole exome sequencing to analyze DNA from 300 children and their families. The study also measures how r…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jul 24, 2026 00:00 UTC