Hyperthyroidism
MONDO:0004425Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Also known as: overactive thyroid
70 clinical trials for this condition and its sub-types, 27 tagged with Hyperthyroidism itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Hyperthyroidism
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Primary hyperthyroidism 1 trial · 59 incl. sub-types
3 sub-types
- Graves disease 53 trials Sub-types →
- Toxic multinodular goitre 7 trials
- Toxic thyroid adenoma 2 trials
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Toxic diffuse goiter 0 trials · 53 incl. sub-types
1 sub-type
- Graves disease 53 trials Sub-types →
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Thyrotoxicosis 2 trials
1 sub-type
- Neonatal thyrotoxicosis 0 trials
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Generalized resistance to thyroid hormone 1 trial · 2 incl. sub-types
6 sub-types
- Thyroid hormone resistance, generalized, autosomal dominant 2 trials
- Athyreosis 0 trials
- Thyroid ectopia 0 trials
- Thyroid hemiagenesis 0 trials
- Thyroid hormone resistance, generalized, autosomal recessive 0 trials
- Thyroid hypoplasia 0 trials
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Secondary hyperthyroidism 0 trials · 2 incl. sub-types
2 sub-types
- TSH producing pituitary tumor 0 trials · 2 incl. sub-types Sub-types →
- Hypothalamic hyperthyroidism 0 trials
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Familial gestational hyperthyroidism 0 trials
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Thyroid crisis 0 trials
Most studied deeper sub-types
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New scan could spot invisible brain tumors
Diagnosis Not yet recruitingThis study tests whether a special PET scan (18FET) can find small pituitary tumors that standard MRI scans miss. About 30 adults with suspected hormone-secreting pituitary tumors will receive the scan. If it works, it could help doctors decide on surgery or radiation without nee…
Phase 2 • Sponsor: University Hospital, Lille • Aim: Diagnosis
Last updated Jun 27, 2026 12:29 UTC
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Can a 4-Minute video ease the stress of radioiodine treatment?
Symptom relief Not yet recruitingThis study tests whether a brief video can help people receiving radioiodine treatment for thyroid conditions feel less distressed and better manage side effects and safety rules. About 80 adults with hyperthyroidism or thyroid cancer will watch either a supportive video or a neu…
Sponsor: University of Auckland, New Zealand • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Two autoimmune conditions, one child: study probes hidden thyroid trouble
Knowledge-focused Not yet recruitingAutoimmune hepatitis makes a child's immune system attack their liver. Researchers at Assiut University Children's Hospital want to know how many children with this liver condition also develop thyroid disorders such as Hashimoto thyroiditis or Graves' disease. The team will test…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
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Eye damage in Graves' disease: can early clues predict who is at risk?
Knowledge-focused Not yet recruitingResearchers at the University of Copenhagen are studying why some people with newly diagnosed Graves' disease develop thyroid eye disease while others do not. The study follows about 430 participants for one year, collecting eye exams, blood and tear samples, and symptom question…
Sponsor: University of Copenhagen • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC