Hydrops fetalis
MONDO:0015193Hydrops fetalis is a severe and challenging fetal condition usually defined as the excessive accumulation of fetal fluid within the fetal extravascular compartments and body cavities that manifests as edema, pleural and pericardial effusion and ascites. It is the end-stage of a wide variety of disorders. The cause may be immunologic (immune hydrops fetalis, IHF) or non immunologic (non-immune hydrops fetalis, NIHF), depending on the presence or absence of maternal antibodies against fetal red cell antigens (ABO incompatibility or rhesus (Rh) incompatibility).
Also known as: HF, fetal anasarca, fetal hydrops, foetal anasarca, foetal hydrops, generalised foetal oedema, generalized fetal edema, hydrops fetalis
7 clinical trials for this condition and its sub-types.
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Broader categories
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New pill may cut blood transfusions for kids with thalassemia
Disease control Recruiting nowThis study tests a drug called mitapivat in children aged 1 to 17 with alpha- or beta-thalassemia who need regular blood transfusions. The goal is to see if mitapivat can reduce the number of transfusions needed compared to a placebo. The study involves 54 participants and lasts …
Phase 3 • Sponsor: Agios Pharmaceuticals, Inc. • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Can a global registry map the path to better outcomes for alpha thalassemia?
Knowledge-focused Recruiting nowThis international registry follows people with alpha thalassemia, a genetic blood disorder, to learn how the disease progresses and how well fetal treatments work. Researchers will track survival to birth, developmental milestones, and health after birth. The goal is to improve …
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC
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New fetal heart monitor could unlock secrets of stillbirth
Knowledge-focused Recruiting nowThis study is testing a new, non-invasive monitor (fetal magnetocardiography) to detect hidden heart problems in high-risk pregnancies that might lead to fetal death. Researchers will study 30 pregnant women with conditions like congenital heart disease or twin pregnancy. The goa…
Sponsor: Medical College of Wisconsin • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC