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Hydrops fetalis
MONDO:0015193Hydrops fetalis is a severe and challenging fetal condition usually defined as the excessive accumulation of fetal fluid within the fetal extravascular compartments and body cavities that manifests as edema, pleural and pericardial effusion and ascites. It is the end-stage of a wide variety of disorders. The cause may be immunologic (immune hydrops fetalis, IHF) or non immunologic (non-immune hydrops fetalis, NIHF), depending on the presence or absence of maternal antibodies against fetal red cell antigens (ABO incompatibility or rhesus (Rh) incompatibility).
Also known as: HF, fetal anasarca, fetal hydrops, foetal anasarca, foetal hydrops, generalised foetal oedema, generalized fetal edema, hydrops fetalis
10 clinical trials for this condition and its sub-types.
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Broader categories
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New genetic sleuthing could solve mysterious fetal swelling cases
Diagnosis Recruiting nowThis study tests whether whole exome and whole genome sequencing can uncover genetic causes of nonimmune fetal hydrops—a serious condition where fluid builds up in a fetus—when standard tests find nothing. Researchers will analyze DNA from 55 affected fetuses or newborns and thei…
Sponsor: Thomas Jefferson University • Aim: Diagnosis
Last updated Jun 26, 2026 15:42 UTC
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Scientists map DNA 'Signatures' in rare fetal diseases
Knowledge-focused Recruiting nowThis study looks at DNA methylation patterns (chemical tags on DNA) in fetuses with rare genetic diseases. Researchers will analyze DNA from amniotic fluid and tissue samples to create reference signatures. The goal is to improve diagnosis of these conditions before birth. The st…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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New fetal heart monitor could unlock secrets of stillbirth
Knowledge-focused Recruiting nowThis study is testing a new, non-invasive monitor (fetal magnetocardiography) to detect hidden heart problems in high-risk pregnancies that might lead to fetal death. Researchers will study 30 pregnant women with conditions like congenital heart disease or twin pregnancy. The goa…
Sponsor: Medical College of Wisconsin • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Gene tests for sick newborns: a lifesaver in the NICU?
Knowledge-focused Recruiting nowThis study is testing whether using rapid genetic sequencing can help doctors diagnose and treat birth defects in newborns in intensive care. Researchers will enroll 2,000 babies and compare death rates, disability rates, and genetic findings. The goal is to see if personalized t…
Sponsor: Children's Hospital of Fudan University • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:36 UTC